Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis
Background and objective: Lithuania belongs to the group of countries with a high-incidence of tuberculosis (TB). Some scientific studies show that the interferon-gamma release assay is more accurate and correlates more highly with TB exposure as compared to the tuberculin skin test (TST). This stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-01-01
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| Series: | Medicina |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1010660X1730037X |
| _version_ | 1797710259385532416 |
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| author | Laura Tamašauskienė Edita Hansted Astra Vitkauskienė Skaidrius Miliauskas Brigita Šitkauskienė |
| author_facet | Laura Tamašauskienė Edita Hansted Astra Vitkauskienė Skaidrius Miliauskas Brigita Šitkauskienė |
| author_sort | Laura Tamašauskienė |
| collection | DOAJ |
| description | Background and objective: Lithuania belongs to the group of countries with a high-incidence of tuberculosis (TB). Some scientific studies show that the interferon-gamma release assay is more accurate and correlates more highly with TB exposure as compared to the tuberculin skin test (TST). This study aimed at comparing the efficacy between the T SPOT TB and TST for diagnosing TB among Lithuanian adults.
Materials and methods: Individuals with diagnosed TB, healthcare workers with known risk for TB and individuals without any known risk for TB underwent clinical examinations, interviews about their history of TB exposure and chest radiography. Then the TST and the T SPOT TB were performed on patients.
Results: A positive T SPOT TB was more common in the group with diagnosed TB compared to healthcare workers and the low risk for TB groups (97.5%, 36.4%, and 0%, respectively, P < 0.01). Positive TST results did not differ between the groups with diagnosed TB and the healthcare workers (92.5% vs. 95.5%, P > 0.05). Agreement between TST and T SPOT TB was poor (kappa 0.14, P > 0.05). T SPOT TB had higher specificity and sensitivity compared to TST (area under the ROC 0.9 ± 0.04, P < 0.01, vs. 0.5 ± 0.06, P > 0.05).
Conclusions: The T SPOT TB showed greater accuracy in diagnosing TB than TST did. Positive T SPOT TB result but not the TST was more common in patients with diagnosed TB. |
| first_indexed | 2024-03-12T06:48:35Z |
| format | Article |
| id | doaj.art-becddcf2666745c393c1fbb921e8be8e |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:48:35Z |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-becddcf2666745c393c1fbb921e8be8e2023-09-03T00:26:23ZengMDPI AGMedicina1010-660X2017-01-0153315916510.1016/j.medici.2017.05.003Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysisLaura Tamašauskienė0Edita Hansted1Astra Vitkauskienė2Skaidrius Miliauskas34Brigita Šitkauskienė5Department of Immunology and Allergology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Paediatrics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Internal Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Immunology and Allergology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaBackground and objective: Lithuania belongs to the group of countries with a high-incidence of tuberculosis (TB). Some scientific studies show that the interferon-gamma release assay is more accurate and correlates more highly with TB exposure as compared to the tuberculin skin test (TST). This study aimed at comparing the efficacy between the T SPOT TB and TST for diagnosing TB among Lithuanian adults. Materials and methods: Individuals with diagnosed TB, healthcare workers with known risk for TB and individuals without any known risk for TB underwent clinical examinations, interviews about their history of TB exposure and chest radiography. Then the TST and the T SPOT TB were performed on patients. Results: A positive T SPOT TB was more common in the group with diagnosed TB compared to healthcare workers and the low risk for TB groups (97.5%, 36.4%, and 0%, respectively, P < 0.01). Positive TST results did not differ between the groups with diagnosed TB and the healthcare workers (92.5% vs. 95.5%, P > 0.05). Agreement between TST and T SPOT TB was poor (kappa 0.14, P > 0.05). T SPOT TB had higher specificity and sensitivity compared to TST (area under the ROC 0.9 ± 0.04, P < 0.01, vs. 0.5 ± 0.06, P > 0.05). Conclusions: The T SPOT TB showed greater accuracy in diagnosing TB than TST did. Positive T SPOT TB result but not the TST was more common in patients with diagnosed TB.http://www.sciencedirect.com/science/article/pii/S1010660X1730037XTuberculosisTuberculin skin testInterferon-gamma release assayT SPOT TB |
| spellingShingle | Laura Tamašauskienė Edita Hansted Astra Vitkauskienė Skaidrius Miliauskas Brigita Šitkauskienė Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis Medicina Tuberculosis Tuberculin skin test Interferon-gamma release assay T SPOT TB |
| title | Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis |
| title_full | Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis |
| title_fullStr | Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis |
| title_full_unstemmed | Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis |
| title_short | Use of interferon-gamma release assay and tuberculin skin test in diagnosing tuberculosis in Lithuanian adults: A comparative analysis |
| title_sort | use of interferon gamma release assay and tuberculin skin test in diagnosing tuberculosis in lithuanian adults a comparative analysis |
| topic | Tuberculosis Tuberculin skin test Interferon-gamma release assay T SPOT TB |
| url | http://www.sciencedirect.com/science/article/pii/S1010660X1730037X |
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