New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers
Background: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffnes...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=4;spage=324;epage=330;aulast=Kassym |
| _version_ | 1818501505431371776 |
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| author | Laura Kassym Mohammed A Nounou Zauresh Zhumadilova Asad I Dajani Nurgul Barkibayeva Ayan Myssayev Tolebay Rakhypbekov Adnan M Abuhammour |
| author_facet | Laura Kassym Mohammed A Nounou Zauresh Zhumadilova Asad I Dajani Nurgul Barkibayeva Ayan Myssayev Tolebay Rakhypbekov Adnan M Abuhammour |
| author_sort | Laura Kassym |
| collection | DOAJ |
| description | Background: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffness was particularly useful in this respect. Acoustic radiation force impulse (ARFI) emerged as an interesting figure tool with reliable repute and high precision. Aims: To evaluate liver stiffness measurement (LSM) and splenic stiffness measurement (SSM) in healthy volunteers as concluded by the ARFI technique and to out a numeric calculated ratio that may reflect their correlation in the otherwise healthy liver. Patients and Methods: A ratio (splenic stiffness/liver stiffness in kPa) was determined in 207 consenting healthy subjects and was investigated with respect to age, gender, ethnic origin, body mass index (BMI), liver and spleen sizes healthy volunteers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelet count (PLT), APRI, and FIB-4 scores. Results: Data from this work led to computing an index of 4.72 (3.42–7.33) in healthy persons on an average. Females had a higher index than males 6.37 vs 4.92, P=0.002. There was not any significant difference of the ratio in different age groups; ethnic origins; any correlation between SSM/LSM ratio and BMI; liver and spleen sizes; or ALT, AST, PLT, APRI, and FIB-4 scores. Conclusions: A quantifiable numeric relationship between splenic and liver stiffness in the healthy subjects could be computed to a parameter expressed as SSM/LSM ratio. We believe that this ratio can be a useful reference tool for further researches in CLD. |
| first_indexed | 2024-12-10T20:57:09Z |
| format | Article |
| id | doaj.art-bece3acd3a4b452ab941b5e9ff79debc |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-10T20:57:09Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-bece3acd3a4b452ab941b5e9ff79debc2022-12-22T01:33:55ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492016-01-0122432433010.4103/1319-3767.187607New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteersLaura KassymMohammed A NounouZauresh ZhumadilovaAsad I DajaniNurgul BarkibayevaAyan MyssayevTolebay RakhypbekovAdnan M AbuhammourBackground: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffness was particularly useful in this respect. Acoustic radiation force impulse (ARFI) emerged as an interesting figure tool with reliable repute and high precision. Aims: To evaluate liver stiffness measurement (LSM) and splenic stiffness measurement (SSM) in healthy volunteers as concluded by the ARFI technique and to out a numeric calculated ratio that may reflect their correlation in the otherwise healthy liver. Patients and Methods: A ratio (splenic stiffness/liver stiffness in kPa) was determined in 207 consenting healthy subjects and was investigated with respect to age, gender, ethnic origin, body mass index (BMI), liver and spleen sizes healthy volunteers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelet count (PLT), APRI, and FIB-4 scores. Results: Data from this work led to computing an index of 4.72 (3.42–7.33) in healthy persons on an average. Females had a higher index than males 6.37 vs 4.92, P=0.002. There was not any significant difference of the ratio in different age groups; ethnic origins; any correlation between SSM/LSM ratio and BMI; liver and spleen sizes; or ALT, AST, PLT, APRI, and FIB-4 scores. Conclusions: A quantifiable numeric relationship between splenic and liver stiffness in the healthy subjects could be computed to a parameter expressed as SSM/LSM ratio. We believe that this ratio can be a useful reference tool for further researches in CLD.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=4;spage=324;epage=330;aulast=KassymARFIelastographyliver stiffnesssplenic stiffness |
| spellingShingle | Laura Kassym Mohammed A Nounou Zauresh Zhumadilova Asad I Dajani Nurgul Barkibayeva Ayan Myssayev Tolebay Rakhypbekov Adnan M Abuhammour New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers The Saudi Journal of Gastroenterology ARFI elastography liver stiffness splenic stiffness |
| title | New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers |
| title_full | New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers |
| title_fullStr | New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers |
| title_full_unstemmed | New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers |
| title_short | New combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers |
| title_sort | new combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers |
| topic | ARFI elastography liver stiffness splenic stiffness |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=4;spage=324;epage=330;aulast=Kassym |
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