Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer
Abstract Background Mesenchymal-epithelial transition exon14 (METex14) skipping is one of the therapeutic driver oncogene mutations in non-small cell lung cancer (NSCLC), and can be treated with tepotinib and capmatinib. There is only one report on computed tomography (CT) findings of METex14 skippi...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-02037-4 |
| _version_ | 1811328797383852032 |
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| author | Naokazu Watari Kakuhiro Yamaguchi Hiroaki Terada Kosuke Hamai Ken Masuda Yoshifumi Nishimura Shinjiro Sakamoto Takeshi Masuda Yasushi Horimasu Shintaro Miyamoto Taku Nakashima Hiroshi Iwamoto Hiroyasu Shoda Nobuhisa Ishikawa Kazunori Fujitaka Kozue Miyazaki Yoshihiro Miyata Hironobu Hamada Kazuo Awai Noboru Hattori |
| author_facet | Naokazu Watari Kakuhiro Yamaguchi Hiroaki Terada Kosuke Hamai Ken Masuda Yoshifumi Nishimura Shinjiro Sakamoto Takeshi Masuda Yasushi Horimasu Shintaro Miyamoto Taku Nakashima Hiroshi Iwamoto Hiroyasu Shoda Nobuhisa Ishikawa Kazunori Fujitaka Kozue Miyazaki Yoshihiro Miyata Hironobu Hamada Kazuo Awai Noboru Hattori |
| author_sort | Naokazu Watari |
| collection | DOAJ |
| description | Abstract Background Mesenchymal-epithelial transition exon14 (METex14) skipping is one of the therapeutic driver oncogene mutations in non-small cell lung cancer (NSCLC), and can be treated with tepotinib and capmatinib. There is only one report on computed tomography (CT) findings of METex14 skipping-positive NSCLC, which shows that the primary tumor tends to have a large mass in the upper lobe, and extrathoracic metastases are common. This study examined the CT findings of METex14 skipping-positive NSCLC, focusing on the features of the margins and internal structures. Methods We consecutively included patients with METex14 skipping-positive NSCLC who were diagnosed between January 2018 and December 2020 at four independent institutions. We retrospectively reviewed the patient demographics and CT findings for tumor margins (invasion into surrounding tissue, lobulation, pleural indentation, spicula, and ground-glass opacity) and internal structures (air bronchograms, cavitation and internal low-density area). Results Fifteen patients with METex14 skipping-positive NSCLC were identified. Almost half of the patients were men (7/15; 46.7%), and their median age was 75.0 years. More than half were either current or former smokers (9/15; 60.0%). A vast majority of histological subtypes were adenocarcinoma (10/15; 66.7%), followed by pleomorphic carcinoma (3/15; 20.0%) and squamous cell carcinoma (2/15; 13.3%). With regard to CT findings, most primary tumors presented as masses larger than 30 mm (12/15; 80.0%) and were located in the upper lobes (12/15; 80.0%). Invasion into surrounding tissue and presence of internal low-density areas were observed in 60.0% (9/15) and 66.7% (10/15) of the primary tumors, respectively. Additionally, their frequencies increased to 72.7% (8/11) and 90.9% (10/11) in stage III/IV cases, respectively. In lymph node metastasis, internal low-density areas were observed in 8/10 cases (80.0%). Although these two CT features were rarely observed in distant metastases at diagnosis, they became apparent with progression of the metastatic tumor size. Conclusions METex14 skipping-positive NSCLC tumors tend to invade surrounding tissue and possess internal low-density areas. These CT findings might be characteristic of METex14 skipping-positive NSCLC. |
| first_indexed | 2024-04-13T15:31:21Z |
| format | Article |
| id | doaj.art-bece7498093044a7bbb19690580de0ce |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-13T15:31:21Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-bece7498093044a7bbb19690580de0ce2022-12-22T02:41:22ZengBMCBMC Pulmonary Medicine1471-24662022-06-012211910.1186/s12890-022-02037-4Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancerNaokazu Watari0Kakuhiro Yamaguchi1Hiroaki Terada2Kosuke Hamai3Ken Masuda4Yoshifumi Nishimura5Shinjiro Sakamoto6Takeshi Masuda7Yasushi Horimasu8Shintaro Miyamoto9Taku Nakashima10Hiroshi Iwamoto11Hiroyasu Shoda12Nobuhisa Ishikawa13Kazunori Fujitaka14Kozue Miyazaki15Yoshihiro Miyata16Hironobu Hamada17Kazuo Awai18Noboru Hattori19Department of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Respiratory Medicine, Hiroshima Prefectural HospitalDepartment of Respiratory Internal Medicine, Hiroshima City Hiroshima Citizens HospitalDepartment of Respiratory Medicine, National Hospital Organization Higashihiroshima Medical CenterDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Internal Medicine, Hiroshima City Hiroshima Citizens HospitalDepartment of Respiratory Medicine, Hiroshima Prefectural HospitalDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Respiratory Medicine, National Hospital Organization Higashihiroshima Medical CenterDepartment of Surgical Oncology, Hiroshima UniversityDepartment of Respiratory Medicine, Hiroshima University HospitalDepartment of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Respiratory Medicine, Hiroshima University HospitalAbstract Background Mesenchymal-epithelial transition exon14 (METex14) skipping is one of the therapeutic driver oncogene mutations in non-small cell lung cancer (NSCLC), and can be treated with tepotinib and capmatinib. There is only one report on computed tomography (CT) findings of METex14 skipping-positive NSCLC, which shows that the primary tumor tends to have a large mass in the upper lobe, and extrathoracic metastases are common. This study examined the CT findings of METex14 skipping-positive NSCLC, focusing on the features of the margins and internal structures. Methods We consecutively included patients with METex14 skipping-positive NSCLC who were diagnosed between January 2018 and December 2020 at four independent institutions. We retrospectively reviewed the patient demographics and CT findings for tumor margins (invasion into surrounding tissue, lobulation, pleural indentation, spicula, and ground-glass opacity) and internal structures (air bronchograms, cavitation and internal low-density area). Results Fifteen patients with METex14 skipping-positive NSCLC were identified. Almost half of the patients were men (7/15; 46.7%), and their median age was 75.0 years. More than half were either current or former smokers (9/15; 60.0%). A vast majority of histological subtypes were adenocarcinoma (10/15; 66.7%), followed by pleomorphic carcinoma (3/15; 20.0%) and squamous cell carcinoma (2/15; 13.3%). With regard to CT findings, most primary tumors presented as masses larger than 30 mm (12/15; 80.0%) and were located in the upper lobes (12/15; 80.0%). Invasion into surrounding tissue and presence of internal low-density areas were observed in 60.0% (9/15) and 66.7% (10/15) of the primary tumors, respectively. Additionally, their frequencies increased to 72.7% (8/11) and 90.9% (10/11) in stage III/IV cases, respectively. In lymph node metastasis, internal low-density areas were observed in 8/10 cases (80.0%). Although these two CT features were rarely observed in distant metastases at diagnosis, they became apparent with progression of the metastatic tumor size. Conclusions METex14 skipping-positive NSCLC tumors tend to invade surrounding tissue and possess internal low-density areas. These CT findings might be characteristic of METex14 skipping-positive NSCLC.https://doi.org/10.1186/s12890-022-02037-4Mesenchymal-epithelial transition exon14 skippingComputed tomographyNon-small cell lung cancerDriver gene mutationImaging examination |
| spellingShingle | Naokazu Watari Kakuhiro Yamaguchi Hiroaki Terada Kosuke Hamai Ken Masuda Yoshifumi Nishimura Shinjiro Sakamoto Takeshi Masuda Yasushi Horimasu Shintaro Miyamoto Taku Nakashima Hiroshi Iwamoto Hiroyasu Shoda Nobuhisa Ishikawa Kazunori Fujitaka Kozue Miyazaki Yoshihiro Miyata Hironobu Hamada Kazuo Awai Noboru Hattori Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer BMC Pulmonary Medicine Mesenchymal-epithelial transition exon14 skipping Computed tomography Non-small cell lung cancer Driver gene mutation Imaging examination |
| title | Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer |
| title_full | Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer |
| title_fullStr | Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer |
| title_full_unstemmed | Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer |
| title_short | Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer |
| title_sort | characteristic computed tomography features in mesenchymal epithelial transition exon14 skipping positive non small cell lung cancer |
| topic | Mesenchymal-epithelial transition exon14 skipping Computed tomography Non-small cell lung cancer Driver gene mutation Imaging examination |
| url | https://doi.org/10.1186/s12890-022-02037-4 |
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