Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology
Organ-on-a-chip (OoC) is an exponential technology with the potential to revolutionize disease, toxicology research, and drug discovery. Recent advances in OoC could be utilized for drug screening in disease models to evaluate the efficacy of new therapies and support new tools for the understanding...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/12/2/215 |
| _version_ | 1797395802507706368 |
|---|---|
| author | Seong-Hye Hwang Sangchul Lee Jee Yoon Park Jessie Sungyun Jeon Young-Jae Cho Sejoong Kim |
| author_facet | Seong-Hye Hwang Sangchul Lee Jee Yoon Park Jessie Sungyun Jeon Young-Jae Cho Sejoong Kim |
| author_sort | Seong-Hye Hwang |
| collection | DOAJ |
| description | Organ-on-a-chip (OoC) is an exponential technology with the potential to revolutionize disease, toxicology research, and drug discovery. Recent advances in OoC could be utilized for drug screening in disease models to evaluate the efficacy of new therapies and support new tools for the understanding of disease mechanisms. Rigorous validation of this technology is required to determine whether OoC models may represent human-relevant physiology and predict clinical outcomes in target disease models. Achievements in the OoC field could reveal exciting new avenues for drug development and discovery. This review attempts to highlight the benefits of OoC as per our understanding of the cellular and molecular pathways in lung and kidney cancer models, and discusses the challenges in evaluating drug efficacy. |
| first_indexed | 2024-03-09T00:40:58Z |
| format | Article |
| id | doaj.art-bece9f206cfd444e8d4ee4f27974492a |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T00:40:58Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-bece9f206cfd444e8d4ee4f27974492a2023-12-11T17:53:04ZengMDPI AGMicromachines2072-666X2021-02-0112221510.3390/mi12020215Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip TechnologySeong-Hye Hwang0Sangchul Lee1Jee Yoon Park2Jessie Sungyun Jeon3Young-Jae Cho4Sejoong Kim5Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Urology, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Mechanical Engineering, KAIST, Daejeon 34141, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaOrgan-on-a-chip (OoC) is an exponential technology with the potential to revolutionize disease, toxicology research, and drug discovery. Recent advances in OoC could be utilized for drug screening in disease models to evaluate the efficacy of new therapies and support new tools for the understanding of disease mechanisms. Rigorous validation of this technology is required to determine whether OoC models may represent human-relevant physiology and predict clinical outcomes in target disease models. Achievements in the OoC field could reveal exciting new avenues for drug development and discovery. This review attempts to highlight the benefits of OoC as per our understanding of the cellular and molecular pathways in lung and kidney cancer models, and discusses the challenges in evaluating drug efficacy.https://www.mdpi.com/2072-666X/12/2/215organ-on-a-chipmicrofluidics technologiesdrug testingcancer modelsdrug efficacy |
| spellingShingle | Seong-Hye Hwang Sangchul Lee Jee Yoon Park Jessie Sungyun Jeon Young-Jae Cho Sejoong Kim Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology Micromachines organ-on-a-chip microfluidics technologies drug testing cancer models drug efficacy |
| title | Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology |
| title_full | Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology |
| title_fullStr | Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology |
| title_full_unstemmed | Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology |
| title_short | Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology |
| title_sort | potential of drug efficacy evaluation in lung and kidney cancer models using organ on a chip technology |
| topic | organ-on-a-chip microfluidics technologies drug testing cancer models drug efficacy |
| url | https://www.mdpi.com/2072-666X/12/2/215 |
| work_keys_str_mv | AT seonghyehwang potentialofdrugefficacyevaluationinlungandkidneycancermodelsusingorganonachiptechnology AT sangchullee potentialofdrugefficacyevaluationinlungandkidneycancermodelsusingorganonachiptechnology AT jeeyoonpark potentialofdrugefficacyevaluationinlungandkidneycancermodelsusingorganonachiptechnology AT jessiesungyunjeon potentialofdrugefficacyevaluationinlungandkidneycancermodelsusingorganonachiptechnology AT youngjaecho potentialofdrugefficacyevaluationinlungandkidneycancermodelsusingorganonachiptechnology AT sejoongkim potentialofdrugefficacyevaluationinlungandkidneycancermodelsusingorganonachiptechnology |