The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review
Single-nucleotide polymorphisms (SNPs) play an essential role in various malignancies, but their role in cholangiocarcinoma (CCA) remains to be elucidated. Therefore, the purpose of this systematic review was to evaluate the association between SNPs and CCA, focusing on tumorigenesis and prognosis....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/23/5969 |
| _version_ | 1797463504971628544 |
|---|---|
| author | Guanwu Wang Lara Rosaline Heij Dong Liu Edgar Dahl Sven Arke LANG Tom Florian Ulmer Tom LUEDDE Ulf Peter Neumann Jan Bednarsch |
| author_facet | Guanwu Wang Lara Rosaline Heij Dong Liu Edgar Dahl Sven Arke LANG Tom Florian Ulmer Tom LUEDDE Ulf Peter Neumann Jan Bednarsch |
| author_sort | Guanwu Wang |
| collection | DOAJ |
| description | Single-nucleotide polymorphisms (SNPs) play an essential role in various malignancies, but their role in cholangiocarcinoma (CCA) remains to be elucidated. Therefore, the purpose of this systematic review was to evaluate the association between SNPs and CCA, focusing on tumorigenesis and prognosis. A systematic literature search was carried out using PubMed, Embase, Web of Science and the Cochrane database for the association between SNPs and CCA, including literature published between January 2000 and April 2022. This systematic review compiles 43 SNPs in 32 genes associated with CCA risk, metastatic progression and overall prognosis based on 34 studies. Susceptibility to CCA was associated with SNPs in genes related to inflammation (PTGS2/COX2, IL6, IFNG/IFN-γ, TNF/TNF-α), DNA repair (ERCC1, MTHFR, MUTYH, XRCC1, OGG1), detoxification (NAT1, NAT2 and ABCC2), enzymes (SERPINA1, GSTO1, APOBEC3A, APOBEC3B), RNA (HOTAIR) and membrane-based proteins (EGFR, GAB1, KLRK1/NKG2D). Overall oncological prognosis was also related to SNPs in eight genes (GNB3, NFE2L2/NRF2, GALNT14, EGFR, XRCC1, EZH2, GNAS, CXCR1). Our findings indicate that multiple SNPs play different roles at various stages of CCA and might serve as biomarkers guiding treatment and allowing oncological risk assessment. Considering the differences in SNP detection methods, patient ethnicity and corresponding environmental factors, more large-scale multicentric investigations are needed to fully determine the potential of SNP analysis for CCA susceptibility prediction and prognostication. |
| first_indexed | 2024-03-09T17:51:39Z |
| format | Article |
| id | doaj.art-bed071a1af554b57b6be28eb3c10e2e8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:51:39Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bed071a1af554b57b6be28eb3c10e2e82023-11-24T10:41:39ZengMDPI AGCancers2072-66942022-12-011423596910.3390/cancers14235969The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic ReviewGuanwu Wang0Lara Rosaline Heij1Dong Liu2Edgar Dahl3Sven Arke LANG4Tom Florian Ulmer5Tom LUEDDE6Ulf Peter Neumann7Jan Bednarsch8Department of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanyInstitute of Pathology, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Heinrich Heine University Duesseldorf, 40225 Duesseldorf, GermanyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, GermanySingle-nucleotide polymorphisms (SNPs) play an essential role in various malignancies, but their role in cholangiocarcinoma (CCA) remains to be elucidated. Therefore, the purpose of this systematic review was to evaluate the association between SNPs and CCA, focusing on tumorigenesis and prognosis. A systematic literature search was carried out using PubMed, Embase, Web of Science and the Cochrane database for the association between SNPs and CCA, including literature published between January 2000 and April 2022. This systematic review compiles 43 SNPs in 32 genes associated with CCA risk, metastatic progression and overall prognosis based on 34 studies. Susceptibility to CCA was associated with SNPs in genes related to inflammation (PTGS2/COX2, IL6, IFNG/IFN-γ, TNF/TNF-α), DNA repair (ERCC1, MTHFR, MUTYH, XRCC1, OGG1), detoxification (NAT1, NAT2 and ABCC2), enzymes (SERPINA1, GSTO1, APOBEC3A, APOBEC3B), RNA (HOTAIR) and membrane-based proteins (EGFR, GAB1, KLRK1/NKG2D). Overall oncological prognosis was also related to SNPs in eight genes (GNB3, NFE2L2/NRF2, GALNT14, EGFR, XRCC1, EZH2, GNAS, CXCR1). Our findings indicate that multiple SNPs play different roles at various stages of CCA and might serve as biomarkers guiding treatment and allowing oncological risk assessment. Considering the differences in SNP detection methods, patient ethnicity and corresponding environmental factors, more large-scale multicentric investigations are needed to fully determine the potential of SNP analysis for CCA susceptibility prediction and prognostication.https://www.mdpi.com/2072-6694/14/23/5969cholangiocarcinomasingle-nucleotide polymorphism (SNP)cancer progressioncancer susceptibilityprognosissystematic review |
| spellingShingle | Guanwu Wang Lara Rosaline Heij Dong Liu Edgar Dahl Sven Arke LANG Tom Florian Ulmer Tom LUEDDE Ulf Peter Neumann Jan Bednarsch The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review Cancers cholangiocarcinoma single-nucleotide polymorphism (SNP) cancer progression cancer susceptibility prognosis systematic review |
| title | The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review |
| title_full | The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review |
| title_fullStr | The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review |
| title_full_unstemmed | The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review |
| title_short | The Role of Single-Nucleotide Polymorphisms in Cholangiocarcinoma: A Systematic Review |
| title_sort | role of single nucleotide polymorphisms in cholangiocarcinoma a systematic review |
| topic | cholangiocarcinoma single-nucleotide polymorphism (SNP) cancer progression cancer susceptibility prognosis systematic review |
| url | https://www.mdpi.com/2072-6694/14/23/5969 |
| work_keys_str_mv | AT guanwuwang theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT lararosalineheij theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT dongliu theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT edgardahl theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT svenarkelang theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT tomflorianulmer theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT tomluedde theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT ulfpeterneumann theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT janbednarsch theroleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT guanwuwang roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT lararosalineheij roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT dongliu roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT edgardahl roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT svenarkelang roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT tomflorianulmer roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT tomluedde roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT ulfpeterneumann roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview AT janbednarsch roleofsinglenucleotidepolymorphismsincholangiocarcinomaasystematicreview |