Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China
PurposeLeptospirosis is a zoonotic disease caused by pathogenic spirochetes of the genus Leptospira. However, there is currently no consensual definition or diagnostic criteria for severe and different forms of leptospirosis. Therefore, more insight on clinical manifestations, risk factors, and outc...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1014530/full |
| _version_ | 1828342967115448320 |
|---|---|
| author | Dianwu Li Dianwu Li Dianwu Li Dianwu Li Dianwu Li Huaying Liang Huaying Liang Huaying Liang Huaying Liang Huaying Liang Rong Yi Qian Xiao Yiqun Zhu Yiqun Zhu Yiqun Zhu Yiqun Zhu Yiqun Zhu Qinyu Chang Qinyu Chang Qinyu Chang Qinyu Chang Qinyu Chang Lihua Zhou Bin Liu Junjun He Tianxing Liu Zhijun Fan Wei Cheng Weizhong Wang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan |
| author_facet | Dianwu Li Dianwu Li Dianwu Li Dianwu Li Dianwu Li Huaying Liang Huaying Liang Huaying Liang Huaying Liang Huaying Liang Rong Yi Qian Xiao Yiqun Zhu Yiqun Zhu Yiqun Zhu Yiqun Zhu Yiqun Zhu Qinyu Chang Qinyu Chang Qinyu Chang Qinyu Chang Qinyu Chang Lihua Zhou Bin Liu Junjun He Tianxing Liu Zhijun Fan Wei Cheng Weizhong Wang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan |
| author_sort | Dianwu Li |
| collection | DOAJ |
| description | PurposeLeptospirosis is a zoonotic disease caused by pathogenic spirochetes of the genus Leptospira. However, there is currently no consensual definition or diagnostic criteria for severe and different forms of leptospirosis. Therefore, more insight on clinical manifestations, risk factors, and outcomes of leptospirosis is warranted. The identification of leptospirosis with distinct clinical manifestations and prognosis in our population.MethodsMultiple correspondence analysis and hierarchical classification on principal components were presented to identify different clinical types of leptospirosis. The outcomes were clinical phenotypes, laboratory and imaging findings, and prognosis.ResultsThe 95 enrolled patients had median values of 54.0 years (39.0-65.0) for age, 9.0 (7.0-14.0) for total hospital stay lengths, of whom 86.3% was male and 40.0% was transferred to ICU. Three clinical types were distinguished: mild leptospirosis (n=43, 45.3%) with less organ dysfunction and shorter hospital stays; respiratory leptospirosis (n=28, 29.5%) with hemoptysis, and respiratory and circulatory failure; and hepato-renal leptospirosis (n=24, 25.3%) with worst liver and kidney dysfunction. Total hospital mortality was 15.8% and was associated with dyspnea and high levels of neutrophil counts.ConclusionsThe identification of leptospirosis with distinct clinical manifestations and prognosis in our population may assist clinicians to distinguish leptospirosis-like disease. Moreover, dyspnea and neutrophil count were found to be independent risk factors for severe leptospirosis progression. |
| first_indexed | 2024-04-13T23:36:32Z |
| format | Article |
| id | doaj.art-bed592298c3e456ca6645ff1463b0d02 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T23:36:32Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-bed592298c3e456ca6645ff1463b0d022022-12-22T02:24:43ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-10-011210.3389/fcimb.2022.10145301014530Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of ChinaDianwu Li0Dianwu Li1Dianwu Li2Dianwu Li3Dianwu Li4Huaying Liang5Huaying Liang6Huaying Liang7Huaying Liang8Huaying Liang9Rong Yi10Qian Xiao11Yiqun Zhu12Yiqun Zhu13Yiqun Zhu14Yiqun Zhu15Yiqun Zhu16Qinyu Chang17Qinyu Chang18Qinyu Chang19Qinyu Chang20Qinyu Chang21Lihua Zhou22Bin Liu23Junjun He24Tianxing Liu25Zhijun Fan26Wei Cheng27Weizhong Wang28Yan Zhang29Yan Zhang30Yan Zhang31Yan Zhang32Yan Zhang33Pinhua Pan34Pinhua Pan35Pinhua Pan36Pinhua Pan37Pinhua Pan38Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou, ChinaDepartment of Anaesthesiology, Hunan Provincial People’s Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, Changsha Central Hospital, Changsha, ChinaDepartment of Emergency, Xiangtan Central Hospital, Xiangtan, China0Department of General Surgery, Shaoyang Central Hospital, Shaoyang, China1Department of Orthopaedic Surgery, Yongzhou Central Hospital, Yongzhou, China2Department of Cardiothoracic Surgery, Liuyang People’s Hospital, Liuyang, China3Department of Respiratory, The Second Xiangya Hospital of Central South University, Changsha, China4Department of Respiratory, The First Affiliated Hospital of University of South China, Hengyang, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, ChinaCenter of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, ChinaClinical Research Center for Respiratory Diseases in Hunan Province, Changsha, ChinaHunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaPurposeLeptospirosis is a zoonotic disease caused by pathogenic spirochetes of the genus Leptospira. However, there is currently no consensual definition or diagnostic criteria for severe and different forms of leptospirosis. Therefore, more insight on clinical manifestations, risk factors, and outcomes of leptospirosis is warranted. The identification of leptospirosis with distinct clinical manifestations and prognosis in our population.MethodsMultiple correspondence analysis and hierarchical classification on principal components were presented to identify different clinical types of leptospirosis. The outcomes were clinical phenotypes, laboratory and imaging findings, and prognosis.ResultsThe 95 enrolled patients had median values of 54.0 years (39.0-65.0) for age, 9.0 (7.0-14.0) for total hospital stay lengths, of whom 86.3% was male and 40.0% was transferred to ICU. Three clinical types were distinguished: mild leptospirosis (n=43, 45.3%) with less organ dysfunction and shorter hospital stays; respiratory leptospirosis (n=28, 29.5%) with hemoptysis, and respiratory and circulatory failure; and hepato-renal leptospirosis (n=24, 25.3%) with worst liver and kidney dysfunction. Total hospital mortality was 15.8% and was associated with dyspnea and high levels of neutrophil counts.ConclusionsThe identification of leptospirosis with distinct clinical manifestations and prognosis in our population may assist clinicians to distinguish leptospirosis-like disease. Moreover, dyspnea and neutrophil count were found to be independent risk factors for severe leptospirosis progression.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1014530/fullleptospirosismortality rateprognosistemperate zoneChina |
| spellingShingle | Dianwu Li Dianwu Li Dianwu Li Dianwu Li Dianwu Li Huaying Liang Huaying Liang Huaying Liang Huaying Liang Huaying Liang Rong Yi Qian Xiao Yiqun Zhu Yiqun Zhu Yiqun Zhu Yiqun Zhu Yiqun Zhu Qinyu Chang Qinyu Chang Qinyu Chang Qinyu Chang Qinyu Chang Lihua Zhou Bin Liu Junjun He Tianxing Liu Zhijun Fan Wei Cheng Weizhong Wang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Yan Zhang Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Pinhua Pan Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China Frontiers in Cellular and Infection Microbiology leptospirosis mortality rate prognosis temperate zone China |
| title | Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China |
| title_full | Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China |
| title_fullStr | Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China |
| title_full_unstemmed | Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China |
| title_short | Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China |
| title_sort | clinical characteristics and prognosis of patient with leptospirosis a multicenter retrospective analysis in south of china |
| topic | leptospirosis mortality rate prognosis temperate zone China |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1014530/full |
| work_keys_str_mv | AT dianwuli clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT dianwuli clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT dianwuli clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT dianwuli clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT dianwuli clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT huayingliang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT huayingliang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT huayingliang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT huayingliang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT huayingliang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT rongyi clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT qianxiao clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yiqunzhu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yiqunzhu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yiqunzhu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yiqunzhu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yiqunzhu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT qinyuchang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT qinyuchang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT qinyuchang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT qinyuchang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT qinyuchang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT lihuazhou clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT binliu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT junjunhe clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT tianxingliu clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT zhijunfan clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT weicheng clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT weizhongwang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yanzhang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yanzhang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yanzhang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yanzhang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT yanzhang clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT pinhuapan clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT pinhuapan clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT pinhuapan clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT pinhuapan clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina AT pinhuapan clinicalcharacteristicsandprognosisofpatientwithleptospirosisamulticenterretrospectiveanalysisinsouthofchina |