Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities
A simple and efficient one-pot three-component synthesis of the biologically important spirooxindole-4H-pyrans was carried out by the reaction of isatin, activated methylene reagents, and 4- hydroxycoumarin in aqueous medium. SBA-Pr-NH2 was found to be an efficient heterogeneous nanoporous solid...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nanoscience and Nanotechnology Research Center, University of Kashan
2012-12-01
|
| Series: | Journal of Nanostructures |
| Subjects: | |
| Online Access: | http://jns.kashanu.ac.ir/article_5422_bc233b6071e0e9ad2080121d582c8705.pdf |
| _version_ | 1818190991801188352 |
|---|---|
| author | G. Mohammadi Ziarani N. Hosseini Mohtasham N. Lashgari A. Badiei M. Amanlou R. Bazl |
| author_facet | G. Mohammadi Ziarani N. Hosseini Mohtasham N. Lashgari A. Badiei M. Amanlou R. Bazl |
| author_sort | G. Mohammadi Ziarani |
| collection | DOAJ |
| description | A simple and efficient one-pot three-component synthesis of the biologically important spirooxindole-4H-pyrans was carried out by the reaction of isatin, activated methylene reagents, and 4- hydroxycoumarin in aqueous medium. SBA-Pr-NH2 was found to be an efficient heterogeneous nanoporous solid basic catalyst (pore size of 6 nm) which can be easily handled and removed from the reaction mixture by simple filtration. This method is of great value because of its environmentally benign character, high yield processing, and easy handling. The biological activity of target compounds was screened by evaluation of their urease enzyme inhibition |
| first_indexed | 2024-12-12T00:07:31Z |
| format | Article |
| id | doaj.art-bedbdf0d4fee442da61b2479ba5d3368 |
| institution | Directory Open Access Journal |
| issn | 2251-7871 2251-788X |
| language | English |
| last_indexed | 2024-12-12T00:07:31Z |
| publishDate | 2012-12-01 |
| publisher | Nanoscience and Nanotechnology Research Center, University of Kashan |
| record_format | Article |
| series | Journal of Nanostructures |
| spelling | doaj.art-bedbdf0d4fee442da61b2479ba5d33682022-12-22T00:45:04ZengNanoscience and Nanotechnology Research Center, University of KashanJournal of Nanostructures2251-78712251-788X2012-12-012448950010.7508/jns.2012.04.0125422Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory ActivitiesG. Mohammadi Ziarani0N. Hosseini Mohtasham1N. Lashgari2A. Badiei3M. Amanlou4R. Bazl5Department of Chemistry, Alzahra University, Tehran, IranDepartment of Chemistry, Alzahra University, Tehran, Irana Department of Chemistry, Alzahra University, Tehran, Iran ,School of Chemistry, College of Science, University of Tehran, Tehran, IranSchool of Chemistry, College of Science, University of Tehran, Tehran, IranDrug Design and Development Research Center and Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDrug Design and Development Research Center and Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranA simple and efficient one-pot three-component synthesis of the biologically important spirooxindole-4H-pyrans was carried out by the reaction of isatin, activated methylene reagents, and 4- hydroxycoumarin in aqueous medium. SBA-Pr-NH2 was found to be an efficient heterogeneous nanoporous solid basic catalyst (pore size of 6 nm) which can be easily handled and removed from the reaction mixture by simple filtration. This method is of great value because of its environmentally benign character, high yield processing, and easy handling. The biological activity of target compounds was screened by evaluation of their urease enzyme inhibitionhttp://jns.kashanu.ac.ir/article_5422_bc233b6071e0e9ad2080121d582c8705.pdfSBA-Pr-NH2Nanoporous catalystGreen synthesisUrease inhibitory |
| spellingShingle | G. Mohammadi Ziarani N. Hosseini Mohtasham N. Lashgari A. Badiei M. Amanlou R. Bazl Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities Journal of Nanostructures SBA-Pr-NH2 Nanoporous catalyst Green synthesis Urease inhibitory |
| title | Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities |
| title_full | Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities |
| title_fullStr | Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities |
| title_full_unstemmed | Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities |
| title_short | Convenient One-Pot Synthesis of Spirooxindole-4H-pyrans in the Presence of SBA-Pr-NH2 and Evaluation of their Urease Inhibitory Activities |
| title_sort | convenient one pot synthesis of spirooxindole 4h pyrans in the presence of sba pr nh2 and evaluation of their urease inhibitory activities |
| topic | SBA-Pr-NH2 Nanoporous catalyst Green synthesis Urease inhibitory |
| url | http://jns.kashanu.ac.ir/article_5422_bc233b6071e0e9ad2080121d582c8705.pdf |
| work_keys_str_mv | AT gmohammadiziarani convenientonepotsynthesisofspirooxindole4hpyransinthepresenceofsbaprnh2andevaluationoftheirureaseinhibitoryactivities AT nhosseinimohtasham convenientonepotsynthesisofspirooxindole4hpyransinthepresenceofsbaprnh2andevaluationoftheirureaseinhibitoryactivities AT nlashgari convenientonepotsynthesisofspirooxindole4hpyransinthepresenceofsbaprnh2andevaluationoftheirureaseinhibitoryactivities AT abadiei convenientonepotsynthesisofspirooxindole4hpyransinthepresenceofsbaprnh2andevaluationoftheirureaseinhibitoryactivities AT mamanlou convenientonepotsynthesisofspirooxindole4hpyransinthepresenceofsbaprnh2andevaluationoftheirureaseinhibitoryactivities AT rbazl convenientonepotsynthesisofspirooxindole4hpyransinthepresenceofsbaprnh2andevaluationoftheirureaseinhibitoryactivities |