Some Molecular Mechanisms of Cervical Ripening
Cervical remodeling is an active dynamic process that begins long before the onset of labor. The optimal course of the cervical ripening/remodeling processes is a prerequisite for successful vaginal delivery. Cervical remodeling is a slow progressive process that begins early in mammalian pregnancie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2020-12-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/i40/ijbm_10(4)_ra3.pdf |
| Summary: | Cervical remodeling is an active dynamic process that begins long before the onset of labor. The optimal course of the cervical ripening/remodeling processes is a prerequisite for successful vaginal delivery. Cervical remodeling is a slow progressive process that begins early in mammalian pregnancies, and can be loosely divided into four overlapping phases termed softening, ripening, dilation/labor, and postpartum repair. This review discusses some aspects of structural changes in the cervix at different stages of cervical ripening. In particular, the role of cervical epithelia, immune-inflammatory factors/cells, and components of the cervical extracellular matrix in cervical ripening is considered. A better understanding of the molecular-biochemical and histophysiological processes occurring during cervical remodeling is critical for the development of novel approaches to treat cervical insufficiency, preterm labor, and postpartum cervical disorders associated with its integrity. |
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| ISSN: | 2158-0510 2158-0529 |