Some Molecular Mechanisms of Cervical Ripening
Cervical remodeling is an active dynamic process that begins long before the onset of labor. The optimal course of the cervical ripening/remodeling processes is a prerequisite for successful vaginal delivery. Cervical remodeling is a slow progressive process that begins early in mammalian pregnancie...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2020-12-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://ijbm.org/articles/i40/ijbm_10(4)_ra3.pdf |
| _version_ | 1818788020878311424 |
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| author | Yu. V. Grigorieva G. N. Suvorova Aleksey M. Chaulin S. N. Yukhimets S. N. Chemidronov V. N. Vankov |
| author_facet | Yu. V. Grigorieva G. N. Suvorova Aleksey M. Chaulin S. N. Yukhimets S. N. Chemidronov V. N. Vankov |
| author_sort | Yu. V. Grigorieva |
| collection | DOAJ |
| description | Cervical remodeling is an active dynamic process that begins long before the onset of labor. The optimal course of the cervical ripening/remodeling processes is a prerequisite for successful vaginal delivery. Cervical remodeling is a slow progressive process that begins early in mammalian pregnancies, and can be loosely divided into four overlapping phases termed softening, ripening, dilation/labor, and postpartum repair. This review discusses some aspects of structural changes in the cervix at different stages of cervical ripening. In particular, the role of cervical epithelia, immune-inflammatory factors/cells, and components of the cervical extracellular matrix in cervical ripening is considered. A better understanding of the molecular-biochemical and histophysiological processes occurring during cervical remodeling is critical for the development of novel approaches to treat cervical insufficiency, preterm labor, and postpartum cervical disorders associated with its integrity. |
| first_indexed | 2024-12-18T14:17:02Z |
| format | Article |
| id | doaj.art-bedbfacc782c4a9fb216a1df1b6b1c21 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-18T14:17:02Z |
| publishDate | 2020-12-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-bedbfacc782c4a9fb216a1df1b6b1c212022-12-21T21:04:59ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292020-12-01104324329Some Molecular Mechanisms of Cervical RipeningYu. V. Grigorieva0G. N. Suvorova1Aleksey M. Chaulin2S. N. Yukhimets3S. N. Chemidronov4V. N. Vankov5Samara State Medical University, Samara, the Russian FederationSamara State Medical University, Samara, the Russian FederationSamara State Medical University, Samara Regional Clinical Cardiology Dispensary, Samara, the Russian FederationREAVIZ Medical University, Samara, the Russian FederationSamara State Medical University, Samara, the Russian FederationSamara State Medical University, Samara Regional Clinical Cardiology Dispensary, Samara, the Russian FederationCervical remodeling is an active dynamic process that begins long before the onset of labor. The optimal course of the cervical ripening/remodeling processes is a prerequisite for successful vaginal delivery. Cervical remodeling is a slow progressive process that begins early in mammalian pregnancies, and can be loosely divided into four overlapping phases termed softening, ripening, dilation/labor, and postpartum repair. This review discusses some aspects of structural changes in the cervix at different stages of cervical ripening. In particular, the role of cervical epithelia, immune-inflammatory factors/cells, and components of the cervical extracellular matrix in cervical ripening is considered. A better understanding of the molecular-biochemical and histophysiological processes occurring during cervical remodeling is critical for the development of novel approaches to treat cervical insufficiency, preterm labor, and postpartum cervical disorders associated with its integrity.http://ijbm.org/articles/i40/ijbm_10(4)_ra3.pdfcervical ripeningextracellular matrixhistophysiological processes |
| spellingShingle | Yu. V. Grigorieva G. N. Suvorova Aleksey M. Chaulin S. N. Yukhimets S. N. Chemidronov V. N. Vankov Some Molecular Mechanisms of Cervical Ripening International Journal of Biomedicine cervical ripening extracellular matrix histophysiological processes |
| title | Some Molecular Mechanisms of Cervical Ripening |
| title_full | Some Molecular Mechanisms of Cervical Ripening |
| title_fullStr | Some Molecular Mechanisms of Cervical Ripening |
| title_full_unstemmed | Some Molecular Mechanisms of Cervical Ripening |
| title_short | Some Molecular Mechanisms of Cervical Ripening |
| title_sort | some molecular mechanisms of cervical ripening |
| topic | cervical ripening extracellular matrix histophysiological processes |
| url | http://ijbm.org/articles/i40/ijbm_10(4)_ra3.pdf |
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