Cyanine conjugates in cancer theranostics
Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but als...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-03-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X20302152 |
| _version_ | 1797204073875767296 |
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| author | Yang Li Yiming Zhou Xiuli Yue Zhifei Dai |
| author_facet | Yang Li Yiming Zhou Xiuli Yue Zhifei Dai |
| author_sort | Yang Li |
| collection | DOAJ |
| description | Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic modality. Herein, we summarize miscellaneous cyanine–therapeutic agent conjugates in cancer theranostics from literature published between 2014 and 2020. The application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities, including chemotherapy, phototherapy and targeted therapy. Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully, accelerate clinical translation in this field. |
| first_indexed | 2024-04-24T08:29:26Z |
| format | Article |
| id | doaj.art-bedc49ea74ca49b2b43c9b35357dbf8b |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:29:26Z |
| publishDate | 2021-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-bedc49ea74ca49b2b43c9b35357dbf8b2024-04-16T20:57:18ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-03-0163794809Cyanine conjugates in cancer theranosticsYang Li0Yiming Zhou1Xiuli Yue2Zhifei Dai3Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, ChinaDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, ChinaSchool of Environment, Harbin Institute of Technology, Harbin 150001, China; Corresponding author.Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China; Corresponding author.Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic modality. Herein, we summarize miscellaneous cyanine–therapeutic agent conjugates in cancer theranostics from literature published between 2014 and 2020. The application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities, including chemotherapy, phototherapy and targeted therapy. Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully, accelerate clinical translation in this field.http://www.sciencedirect.com/science/article/pii/S2452199X20302152Cyanine conjugateCancer theranosticsTherapeutic agentNanocarrierClinical translation |
| spellingShingle | Yang Li Yiming Zhou Xiuli Yue Zhifei Dai Cyanine conjugates in cancer theranostics Bioactive Materials Cyanine conjugate Cancer theranostics Therapeutic agent Nanocarrier Clinical translation |
| title | Cyanine conjugates in cancer theranostics |
| title_full | Cyanine conjugates in cancer theranostics |
| title_fullStr | Cyanine conjugates in cancer theranostics |
| title_full_unstemmed | Cyanine conjugates in cancer theranostics |
| title_short | Cyanine conjugates in cancer theranostics |
| title_sort | cyanine conjugates in cancer theranostics |
| topic | Cyanine conjugate Cancer theranostics Therapeutic agent Nanocarrier Clinical translation |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X20302152 |
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