MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results
Abstract Objectives To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-022-01269-6 |
| _version_ | 1798000675029778432 |
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| author | Qingling Song Huiting Pang Rui Tong Yanmei Zhu Yahong Luo Tao Yu Fan Liu Yue Dong |
| author_facet | Qingling Song Huiting Pang Rui Tong Yanmei Zhu Yahong Luo Tao Yu Fan Liu Yue Dong |
| author_sort | Qingling Song |
| collection | DOAJ |
| description | Abstract Objectives To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of different treatment strategies in the patients. Methods A total of 149 patients with IB2 and IIA2 SCC who underwent pretreatment MRI and DWI scan were included. Patients were treated with NAT + RH or CCRT. Clinical indices and pathological factors were recorded. The imaging indices were measured including tumor size and tumor ADC values. Intraclass correlation coefficient was employed to evaluate the consistency of the indices measured by two observers. ROC curves were used to evaluate the cutoff values of clinical and imaging indices. Kaplan–Meier and Cox proportional hazard model were used to analyze the independent factors of disease-free survival (DFS). Results The median follow-up period was 42.3 months. SCC-Ag, ADCmax and ADCmin were independent factors for DFS in the entire cohort. SCC-Ag, ADCmin and vascular invasion were independent factors for DFS in NAT + RH group. ADCmax and ADCmin were independent factors for DFS in CCRT group. ADCmin was the strongest independent factor for DFS in NAT + RH group, while ADCmax was that in CCRT group. Conclusion The NAT + RH patients had similar DFS to that of CCRT in IB2 and IIA2 SCC, which could be a potential feasible alternative treatment. ADCmin and ADCmax were more valuable in evaluating the outcome of patients who underwent NAT + RH or CCRT, respectively. |
| first_indexed | 2024-04-11T11:24:08Z |
| format | Article |
| id | doaj.art-bedd2daa107c4614808bcac3bbe01a00 |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-04-11T11:24:08Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-bedd2daa107c4614808bcac3bbe01a002022-12-22T04:26:21ZengSpringerOpenInsights into Imaging1869-41012022-09-0113111210.1186/s13244-022-01269-6MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary resultsQingling Song0Huiting Pang1Rui Tong2Yanmei Zhu3Yahong Luo4Tao Yu5Fan Liu6Yue Dong7Graduate School of Dalian Medical UniversityDepartment of Radiology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteDepartment of Gynecology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteDepartment of Pathology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteDepartment of Radiology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteDepartment of Radiology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteDepartment of Radiology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteDepartment of Radiology, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & InstituteAbstract Objectives To evaluate the therapeutic effect of neoadjuvant therapy (NAT) followed by radical hysterectomy and concurrent chemoradiotherapy (CCRT) in stage IB2 and IIA2 squamous cervical cancer (SCC) and investigate the value of apparent diffusion coefficient (ADC) in outcome evaluation of different treatment strategies in the patients. Methods A total of 149 patients with IB2 and IIA2 SCC who underwent pretreatment MRI and DWI scan were included. Patients were treated with NAT + RH or CCRT. Clinical indices and pathological factors were recorded. The imaging indices were measured including tumor size and tumor ADC values. Intraclass correlation coefficient was employed to evaluate the consistency of the indices measured by two observers. ROC curves were used to evaluate the cutoff values of clinical and imaging indices. Kaplan–Meier and Cox proportional hazard model were used to analyze the independent factors of disease-free survival (DFS). Results The median follow-up period was 42.3 months. SCC-Ag, ADCmax and ADCmin were independent factors for DFS in the entire cohort. SCC-Ag, ADCmin and vascular invasion were independent factors for DFS in NAT + RH group. ADCmax and ADCmin were independent factors for DFS in CCRT group. ADCmin was the strongest independent factor for DFS in NAT + RH group, while ADCmax was that in CCRT group. Conclusion The NAT + RH patients had similar DFS to that of CCRT in IB2 and IIA2 SCC, which could be a potential feasible alternative treatment. ADCmin and ADCmax were more valuable in evaluating the outcome of patients who underwent NAT + RH or CCRT, respectively.https://doi.org/10.1186/s13244-022-01269-6MRISquamous cervical cancerDisease-free survivalNeoadjuvant therapyConcurrent chemoradiotherapy |
| spellingShingle | Qingling Song Huiting Pang Rui Tong Yanmei Zhu Yahong Luo Tao Yu Fan Liu Yue Dong MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results Insights into Imaging MRI Squamous cervical cancer Disease-free survival Neoadjuvant therapy Concurrent chemoradiotherapy |
| title | MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results |
| title_full | MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results |
| title_fullStr | MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results |
| title_full_unstemmed | MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results |
| title_short | MRI outcome evaluation in patients with IB2 and IIA2 squamous cervical cancer stages: preliminary results |
| title_sort | mri outcome evaluation in patients with ib2 and iia2 squamous cervical cancer stages preliminary results |
| topic | MRI Squamous cervical cancer Disease-free survival Neoadjuvant therapy Concurrent chemoradiotherapy |
| url | https://doi.org/10.1186/s13244-022-01269-6 |
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