16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons

16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons

16p13.11 copy number variants (CNVs) have been associated with autism, schizophrenia, psychosis, intellectual disability, and epilepsy. The majority of 16p13.11 deletions or duplications occur within three well-defined intervals, and despite growing knowledge of the functions of individual genes wit...

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Bibliographic Details
Main Authors: Elizabeth D. Buttermore, Nickesha C. Anderson, Pin-Fang Chen, Nina R. Makhortova, Kristina H. Kim, Syed M. A. Wafa, Sean Dwyer, John M. Micozzi, Kellen D. Winden, Bo Zhang, Min-Joon Han, Robin J. Kleiman, Catherine A. Brownstein, Mustafa Sahin, Joseph Gonzalez-Heydrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Psychiatry
Subjects:
iPSC-derived neurons
neuropsychiatric disorders
16p13.11 deletion
neurite morphology
synapses
in vitro modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.924956/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.924956/full

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