Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria
Introduction: Low Birth Weight (LBW) is associated with poor health conditions during neonatal period, infancy and in adult life. It is possible that some form of fetal growth restriction occurs in babies of HIV sero-positive women. Aim: To determine the effect of maternal HIV infection on neonatal...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2019-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/13361/42918_F(KM)_CE[Ra1]_KM_PF1(AKA_SL)_PFA(KM)_PN(SL).pdf |
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| author | Emeka Ifeanyi Iloghalu Cyril Chukwudi Dim Emmanuel Onyebuchi Ugwu Chidinma Ifechi Onwuka Benjamin Chukwuma Ozumba |
| author_facet | Emeka Ifeanyi Iloghalu Cyril Chukwudi Dim Emmanuel Onyebuchi Ugwu Chidinma Ifechi Onwuka Benjamin Chukwuma Ozumba |
| author_sort | Emeka Ifeanyi Iloghalu |
| collection | DOAJ |
| description | Introduction: Low Birth Weight (LBW) is associated with poor health conditions during neonatal period, infancy and in adult life. It is possible that some form of fetal growth restriction occurs in babies of HIV sero-positive women. Aim: To determine the effect of maternal HIV infection on neonatal birth weight and other neonatal anthropometric indices. Materials and Methods: The study was prospective cohort in design. Neonatal birth weight, head circumference, and crownheel length of babies of 87 consecutive consenting HAART experienced HIV sero-positive pregnant women on HAART (study group) were compared with those of 92 matched HIV sero-negative women (control group). Data analyses were both descriptive and inferential at 95% confidence level. Results: The incidence of low birth weight was 25.3% (22/87) among the HIV sero-positive group and 14.1% (13/92) among the control group (p=0.060, R.R=1.8, 95% CI: 0.96-3.33). The mean neonatal head circumference in the study and control groups were 33.7±2.93 cm and 34.5±2.31 cm respectively, p=0.036 while the mean crown-heel length was 47.9±4.59 cm versus 48.7±4.02 cm, p=0.217. Conclusion: Maternal HIV treatment with Highly Active Antiretroviral Therapy (HAART) was not associated with high incidence LBW in Enugu, Nigeria. However, the head circumference was reduced. Careful measurement of the head circumferences of neonates of HIV sero-positive mothers, during routine new-born examination, is encouraged, so that any disproportionate growth would receive further appropriate assessment. |
| first_indexed | 2024-04-13T15:24:49Z |
| format | Article |
| id | doaj.art-bee10781c57a4adeb8773a05f0fee6b6 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T15:24:49Z |
| publishDate | 2019-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-bee10781c57a4adeb8773a05f0fee6b62022-12-22T02:41:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2019-12-011312QC01QC0410.7860/JCDR/2019/42918.13361Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East NigeriaEmeka Ifeanyi Iloghalu0Cyril Chukwudi Dim1Emmanuel Onyebuchi Ugwu2Chidinma Ifechi Onwuka3Benjamin Chukwuma Ozumba4Lecturer/Consultant, Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria/University of Nigeria Teaching Hospital Ituku Ozalla Cam, Ituku/Ozalla, Enugu, Nigeria.Professor/ Consultant, Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria/University of Nigeria Teaching Hospital Ituku Ozalla Cam, Ituku/Ozalla, Enugu, Nigeria.Associate Professor/Consultant, Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria/University of Nigeria Teaching Hospital Ituku Ozalla Cam, Ituku/Ozalla, Enugu, Nigeria.Senior Lecturer/ Consultant, Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria/University of Nigeria Teaching Hospital Ituku Ozalla Cam, Ituku/Ozalla, Enugu, Nigeria.Professor/Consultant, Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria/University of Nigeria Teaching Hospital Ituku Ozalla Cam, Ituku/Ozalla, Enugu, Nigeria.Introduction: Low Birth Weight (LBW) is associated with poor health conditions during neonatal period, infancy and in adult life. It is possible that some form of fetal growth restriction occurs in babies of HIV sero-positive women. Aim: To determine the effect of maternal HIV infection on neonatal birth weight and other neonatal anthropometric indices. Materials and Methods: The study was prospective cohort in design. Neonatal birth weight, head circumference, and crownheel length of babies of 87 consecutive consenting HAART experienced HIV sero-positive pregnant women on HAART (study group) were compared with those of 92 matched HIV sero-negative women (control group). Data analyses were both descriptive and inferential at 95% confidence level. Results: The incidence of low birth weight was 25.3% (22/87) among the HIV sero-positive group and 14.1% (13/92) among the control group (p=0.060, R.R=1.8, 95% CI: 0.96-3.33). The mean neonatal head circumference in the study and control groups were 33.7±2.93 cm and 34.5±2.31 cm respectively, p=0.036 while the mean crown-heel length was 47.9±4.59 cm versus 48.7±4.02 cm, p=0.217. Conclusion: Maternal HIV treatment with Highly Active Antiretroviral Therapy (HAART) was not associated with high incidence LBW in Enugu, Nigeria. However, the head circumference was reduced. Careful measurement of the head circumferences of neonates of HIV sero-positive mothers, during routine new-born examination, is encouraged, so that any disproportionate growth would receive further appropriate assessment.https://jcdr.net/articles/PDF/13361/42918_F(KM)_CE[Ra1]_KM_PF1(AKA_SL)_PFA(KM)_PN(SL).pdfcrown-heal lengthhaart experiencedhead circumferencelow birth weightmaternal hiv sero-positivity |
| spellingShingle | Emeka Ifeanyi Iloghalu Cyril Chukwudi Dim Emmanuel Onyebuchi Ugwu Chidinma Ifechi Onwuka Benjamin Chukwuma Ozumba Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria Journal of Clinical and Diagnostic Research crown-heal length haart experienced head circumference low birth weight maternal hiv sero-positivity |
| title | Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria |
| title_full | Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria |
| title_fullStr | Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria |
| title_full_unstemmed | Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria |
| title_short | Effect of Maternal HIV Infection on Treatment with HAART on Neonatal Birth Weight and Other Anthropometry: A Cohort Study of HIV Sero-Positive Women in Enugu, South-East Nigeria |
| title_sort | effect of maternal hiv infection on treatment with haart on neonatal birth weight and other anthropometry a cohort study of hiv sero positive women in enugu south east nigeria |
| topic | crown-heal length haart experienced head circumference low birth weight maternal hiv sero-positivity |
| url | https://jcdr.net/articles/PDF/13361/42918_F(KM)_CE[Ra1]_KM_PF1(AKA_SL)_PFA(KM)_PN(SL).pdf |
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