Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy
Objective: The evaluation of the relationships between the mortality and early period laboratory tests in the term infants diagnosed as hypoxic ischemic encephalopathy (HIE).Material and Methods: The newborns diagnosed as HIE between January 2004 and December 2008 were divided into two groups as the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2011-09-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://tutfd.org/text.php3?id=772 |
| _version_ | 1797910934896771072 |
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| author | Emrah Can Ali Bülbül Asiye Nuhoğlu |
| author_facet | Emrah Can Ali Bülbül Asiye Nuhoğlu |
| author_sort | Emrah Can |
| collection | DOAJ |
| description | Objective: The evaluation of the relationships between the mortality and early period laboratory tests in the term infants diagnosed as hypoxic ischemic encephalopathy (HIE).Material and Methods: The newborns diagnosed as HIE between January 2004 and December 2008 were divided into two groups as the living and non-surviving groups. The two groups were evaluated prospectively.Results: Thirty two infants were included in the study. According to the Sarnat&Sarnat classification, 9 (28.1%), 14 (43.8%) and 9 infants (28.1%) were in stage 1, 2 and 3, respectively. Eight (25%) infants died. In the correlation evaluation of risk factors; lack of-follow-up at the antenatal period (r²=0.35) and having convulsions (r²=0.50) were positively associated with Sarnat stage. A positive relationship between Sarnat stage and the mortality rate was also determined (r²=0.57). CK-MB was strongly (r²=0.74), troponin-I moderately (r²=0.44), and pH weakly (r²=0.27) associated with mortality. In predicting mortality, the sensitivity and specificity for CK-MB was 100% and 91.6%, for Troponin I 100% and 70.8% and for pH 75% and 87.5%, respectively.Conclusion: This study demonstrates that in HIE, the relationship between the early period mortality rate and CK- MB values are strong, whereas for troponin-I and pH there is a moderate and weak association respectively. |
| first_indexed | 2024-04-10T11:33:31Z |
| format | Article |
| id | doaj.art-bee1389670d5407b941cf1002d9ec432 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T11:33:31Z |
| publishDate | 2011-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-bee1389670d5407b941cf1002d9ec4322023-02-15T16:18:00ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312011-09-012803256260Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic EncephalopathyEmrah CanAli BülbülAsiye NuhoğluObjective: The evaluation of the relationships between the mortality and early period laboratory tests in the term infants diagnosed as hypoxic ischemic encephalopathy (HIE).Material and Methods: The newborns diagnosed as HIE between January 2004 and December 2008 were divided into two groups as the living and non-surviving groups. The two groups were evaluated prospectively.Results: Thirty two infants were included in the study. According to the Sarnat&Sarnat classification, 9 (28.1%), 14 (43.8%) and 9 infants (28.1%) were in stage 1, 2 and 3, respectively. Eight (25%) infants died. In the correlation evaluation of risk factors; lack of-follow-up at the antenatal period (r²=0.35) and having convulsions (r²=0.50) were positively associated with Sarnat stage. A positive relationship between Sarnat stage and the mortality rate was also determined (r²=0.57). CK-MB was strongly (r²=0.74), troponin-I moderately (r²=0.44), and pH weakly (r²=0.27) associated with mortality. In predicting mortality, the sensitivity and specificity for CK-MB was 100% and 91.6%, for Troponin I 100% and 70.8% and for pH 75% and 87.5%, respectively.Conclusion: This study demonstrates that in HIE, the relationship between the early period mortality rate and CK- MB values are strong, whereas for troponin-I and pH there is a moderate and weak association respectively.http://tutfd.org/text.php3?id=772Hypoxic-ischemic encephalopathymortalityCK-MBtroponin Inewborn |
| spellingShingle | Emrah Can Ali Bülbül Asiye Nuhoğlu Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy Balkan Medical Journal Hypoxic-ischemic encephalopathy mortality CK-MB troponin I newborn |
| title | Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy |
| title_full | Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy |
| title_fullStr | Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy |
| title_full_unstemmed | Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy |
| title_short | Evaluation of the Association of Laboratory Tests Associated with Mortality in Term Neonates with Hypoxic-Ischemic Encephalopathy |
| title_sort | evaluation of the association of laboratory tests associated with mortality in term neonates with hypoxic ischemic encephalopathy |
| topic | Hypoxic-ischemic encephalopathy mortality CK-MB troponin I newborn |
| url | http://tutfd.org/text.php3?id=772 |
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