Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections
It is well-established that botulinum toxin (BT) injections improve quality of life in patients with postparalytic hemifacial spasm. Nevertheless, injection-related pain and contracture-related pain have not yet been studied. The primary objective of our study was to evaluate injection-related pain...
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MDPI AG
2021-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/14/1/20 |
| _version_ | 1797490023158775808 |
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| author | Chloé Wehrlin Diane Picard Frederic Tankéré Rémi Hervochon Claire Foirest |
| author_facet | Chloé Wehrlin Diane Picard Frederic Tankéré Rémi Hervochon Claire Foirest |
| author_sort | Chloé Wehrlin |
| collection | DOAJ |
| description | It is well-established that botulinum toxin (BT) injections improve quality of life in patients with postparalytic hemifacial spasm. Nevertheless, injection-related pain and contracture-related pain have not yet been studied. The primary objective of our study was to evaluate injection-related pain in patients with facial palsy sequelae, and to compare the standard technique (syringe) with the Juvapen device. The secondary objective was to evaluate the improvement of contracture-related pain one month after BT injection. Methods: We conducted an observational, prospective, monocentric study based on 60 patients with facial palsy sequelae who received BT injections in our university ENT (ear, nose throat) department. There were 30 patients in the Juvapen group (J) and 30 in the standard technique group (ST). All patients completed Numerical Rating Scale (NRS) questionnaires immediately after the injections and one month later. Results: The average NRS score was 1.33/10 with Juvapen and 2.24/10 with the standard technique (<i>p</i> = 0.0058; Z = 2.75). In patients with contracture-related pain, the average NRS score was 3.53 before BT injection, and 0.41 one month after BT injection (<i>p</i> = 0.0001). Conclusions: Juvapen is a less-painful injection technique than the standard one. BT reduces contracture-related pain one month after injection. |
| first_indexed | 2024-03-10T00:25:03Z |
| format | Article |
| id | doaj.art-bee3fa1e5b0b48aeb262a7a9fce093ff |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T00:25:03Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-bee3fa1e5b0b48aeb262a7a9fce093ff2023-11-23T15:35:43ZengMDPI AGToxins2072-66512021-12-011412010.3390/toxins14010020Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin InjectionsChloé Wehrlin0Diane Picard1Frederic Tankéré2Rémi Hervochon3Claire Foirest4ENT Department, Pitié Salpêtrière Hospital, Sorbonne Université, 75013 Paris, FranceENT Department, Pitié Salpêtrière Hospital, Sorbonne Université, 75013 Paris, FranceENT Department, Pitié Salpêtrière Hospital, Sorbonne Université, 75013 Paris, FranceENT Department, Pitié Salpêtrière Hospital, Sorbonne Université, 75013 Paris, FranceENT Department, Pitié Salpêtrière Hospital, Sorbonne Université, 75013 Paris, FranceIt is well-established that botulinum toxin (BT) injections improve quality of life in patients with postparalytic hemifacial spasm. Nevertheless, injection-related pain and contracture-related pain have not yet been studied. The primary objective of our study was to evaluate injection-related pain in patients with facial palsy sequelae, and to compare the standard technique (syringe) with the Juvapen device. The secondary objective was to evaluate the improvement of contracture-related pain one month after BT injection. Methods: We conducted an observational, prospective, monocentric study based on 60 patients with facial palsy sequelae who received BT injections in our university ENT (ear, nose throat) department. There were 30 patients in the Juvapen group (J) and 30 in the standard technique group (ST). All patients completed Numerical Rating Scale (NRS) questionnaires immediately after the injections and one month later. Results: The average NRS score was 1.33/10 with Juvapen and 2.24/10 with the standard technique (<i>p</i> = 0.0058; Z = 2.75). In patients with contracture-related pain, the average NRS score was 3.53 before BT injection, and 0.41 one month after BT injection (<i>p</i> = 0.0001). Conclusions: Juvapen is a less-painful injection technique than the standard one. BT reduces contracture-related pain one month after injection.https://www.mdpi.com/2072-6651/14/1/20facial palsypainbotulinum toxin |
| spellingShingle | Chloé Wehrlin Diane Picard Frederic Tankéré Rémi Hervochon Claire Foirest Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections Toxins facial palsy pain botulinum toxin |
| title | Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections |
| title_full | Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections |
| title_fullStr | Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections |
| title_full_unstemmed | Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections |
| title_short | Pain in Patients with Post Paralytic Hemifacial Spasm: Before, during and after Botulinum Toxin Injections |
| title_sort | pain in patients with post paralytic hemifacial spasm before during and after botulinum toxin injections |
| topic | facial palsy pain botulinum toxin |
| url | https://www.mdpi.com/2072-6651/14/1/20 |
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