Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region
Abstract Background The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-06-01
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| Series: | Clinical and Translational Allergy |
| Online Access: | http://link.springer.com/article/10.1186/s13601-018-0207-x |
| _version_ | 1818723957216378880 |
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| author | Petr Panzner Martina Vachová Tomáš Vlas Petra Vítovcová Petra Brodská Marek Malý |
| author_facet | Petr Panzner Martina Vachová Tomáš Vlas Petra Vítovcová Petra Brodská Marek Malý |
| author_sort | Petr Panzner |
| collection | DOAJ |
| description | Abstract Background The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach. We used molecular diagnosis by means of the microarray ISAC, and we investigated 1766 patients with clinical suspicion to an allergic disorder. 1255 of them were positive to at least one allergen component, and this group was subjected to statistical analysis. Results The sensitization to at least one mite-specific molecule (Der p 1, 2, Der f 1, 2) was observed relatively frequently in 32.7% of patients. Specific IgE to mite group 2 molecules is almost fully cross-reactive. Group 1 allergens are also cross-reactive, but in some patients, a species-specific response was observed. Relatively high rate of sensitization both to group 1 and 2 allergens in our patients indicates the greater role of co-sensitizations. Isolated sensitizations to molecules derived from glyciphagid mites Lep d 2 and/or Blo t 5 without sensitization to other mite-derived molecules were observed only exceptionally (in 0.6% of cases). True sensitization to at least one cockroach-specific molecule (Bla g 1, 2, 5) was very rare (in 0.6% of cases), and nearly all of them were co-sensitizations with other noncockroach-derived molecules. Sensitization to an inhaled tropomyosin was observed rarely in 2.2% of patients (Der p 10 in 1.9% and Bla g 7 in 1.5%). Co-sensitization of inhaled tropomyosins with the respective mite- or cockroach-specific molecules was observed only in the minority of patients suggesting the different route of sensitization being more frequent. Conclusions The majority of patients are co-sensitized to several molecules of the respective allergen source. The knowledge of this molecular spectrum of sensitization is important for optimal diagnosis and treatment in respect to allergen content in mite extracts used for diagnostic and therapeutic purposes. In regard to the sensitization patterns of Central European patients, it is necessary to point out the importance of quantifying at least three major mite components Der f 1, Der p 1 and Der f 2 (or Der p 2). |
| first_indexed | 2024-12-17T21:18:46Z |
| format | Article |
| id | doaj.art-bee5225d48c549e2b44e61be87e235c4 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-12-17T21:18:46Z |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-bee5225d48c549e2b44e61be87e235c42022-12-21T21:32:16ZengWileyClinical and Translational Allergy2045-70222018-06-01811910.1186/s13601-018-0207-xCross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European regionPetr Panzner0Martina Vachová1Tomáš Vlas2Petra Vítovcová3Petra Brodská4Marek Malý5Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles UniversityDepartment of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles UniversityDepartment of Immunology and Allergology, Faculty Hospital in PilsenDepartment of Immunology and Allergology, Faculty Hospital in PilsenDepartment of Dermatovenerology, Faculty Hospital in PilsenThe National Institute of Public HealthAbstract Background The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach. We used molecular diagnosis by means of the microarray ISAC, and we investigated 1766 patients with clinical suspicion to an allergic disorder. 1255 of them were positive to at least one allergen component, and this group was subjected to statistical analysis. Results The sensitization to at least one mite-specific molecule (Der p 1, 2, Der f 1, 2) was observed relatively frequently in 32.7% of patients. Specific IgE to mite group 2 molecules is almost fully cross-reactive. Group 1 allergens are also cross-reactive, but in some patients, a species-specific response was observed. Relatively high rate of sensitization both to group 1 and 2 allergens in our patients indicates the greater role of co-sensitizations. Isolated sensitizations to molecules derived from glyciphagid mites Lep d 2 and/or Blo t 5 without sensitization to other mite-derived molecules were observed only exceptionally (in 0.6% of cases). True sensitization to at least one cockroach-specific molecule (Bla g 1, 2, 5) was very rare (in 0.6% of cases), and nearly all of them were co-sensitizations with other noncockroach-derived molecules. Sensitization to an inhaled tropomyosin was observed rarely in 2.2% of patients (Der p 10 in 1.9% and Bla g 7 in 1.5%). Co-sensitization of inhaled tropomyosins with the respective mite- or cockroach-specific molecules was observed only in the minority of patients suggesting the different route of sensitization being more frequent. Conclusions The majority of patients are co-sensitized to several molecules of the respective allergen source. The knowledge of this molecular spectrum of sensitization is important for optimal diagnosis and treatment in respect to allergen content in mite extracts used for diagnostic and therapeutic purposes. In regard to the sensitization patterns of Central European patients, it is necessary to point out the importance of quantifying at least three major mite components Der f 1, Der p 1 and Der f 2 (or Der p 2).http://link.springer.com/article/10.1186/s13601-018-0207-x |
| spellingShingle | Petr Panzner Martina Vachová Tomáš Vlas Petra Vítovcová Petra Brodská Marek Malý Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region Clinical and Translational Allergy |
| title | Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region |
| title_full | Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region |
| title_fullStr | Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region |
| title_full_unstemmed | Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region |
| title_short | Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region |
| title_sort | cross sectional study on sensitization to mite and cockroach allergen components in allergy patients in the central european region |
| url | http://link.springer.com/article/10.1186/s13601-018-0207-x |
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