CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells

CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype th...

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Main Authors: Ayako Kurioka, Cormac Cosgrove, Yannick Simoni, Bonnie van Wilgenburg, Alessandra Geremia, Sophia Björkander, Eva Sverremark-Ekström, Christine Thurnheer, Huldrych F. Günthard, Nina Khanna, The Swiss HIV Cohort Study, Oxford IBD Cohort Investigators, Lucy Jane Walker, Carolina V. Arancibia-Cárcamo, Evan W. Newell, Christian B. Willberg, Paul Klenerman, V Aubert, M Battegay, E Bernasconi, J Böni, DL Braun, HC Bucher, C Burton-Jeangros, A Calmy, M Cavassini, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, C Marzolini, K Metzner, N Müller, D Nadal, D Nicca, G Pantaleo, A Rauch, S Regenass, C Rudin, A Scherrer, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, P Vernazza, R Weber, S Yerly, CV Arancibia-Cárcamo, A Bailey, E Barnes, B Bird-Lieberman, O Brain, B Braden, J Collier, J East, A Geremia, L Howarth, S Keshav, P Klenerman, S Leedham, R Palmer, F Powrie, A Rodrigues, A Simmons, P Sullivan, SPL Travis, H Uhlig
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
CD161
pro-inflammatory cytokines
cytomegalovirus
human immunodeficiency virus
inflammatory bowel diseases
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00486/full

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