Roles for the Dorsal Striatum in Aversive Behavior
The ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum. Rela...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2021-02-01
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Series: | Frontiers in Cellular Neuroscience |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.634493/full |
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author | Adrien T. Stanley Pellegrino Lippiello David Sulzer David Sulzer Maria Concetta Miniaci |
author_facet | Adrien T. Stanley Pellegrino Lippiello David Sulzer David Sulzer Maria Concetta Miniaci |
author_sort | Adrien T. Stanley |
collection | DOAJ |
description | The ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum. Relatively little attention has been paid to contributions from the dorsal striatum (DS) to aversive learning, despite its well-established role in stimulus-response learning. Here, we review studies exploring the role of DS in aversive learning, including different roles for the dorsomedial and dorsolateral striatum in Pavlovian fear conditioning as well as innate and inhibitory avoidance (IA) behaviors. We outline how future investigation might determine specific contributions from DS subregions, cell types, and connections that contribute to aversive behavior. |
first_indexed | 2024-12-14T23:47:24Z |
format | Article |
id | doaj.art-bee8b933cf9642738a9253a52b877900 |
institution | Directory Open Access Journal |
issn | 1662-5102 |
language | English |
last_indexed | 2024-12-14T23:47:24Z |
publishDate | 2021-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Cellular Neuroscience |
spelling | doaj.art-bee8b933cf9642738a9253a52b8779002022-12-21T22:43:20ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-02-011510.3389/fncel.2021.634493634493Roles for the Dorsal Striatum in Aversive BehaviorAdrien T. Stanley0Pellegrino Lippiello1David Sulzer2David Sulzer3Maria Concetta Miniaci4Departments of Biology and Psychiatry, Columbia University, New York, NY, United StatesDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, ItalyDepartments of Psychiatry, Neurology, and Pharmacology, Columbia University Medical Center, New York, NY, United StatesDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United StatesDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, ItalyThe ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum. Relatively little attention has been paid to contributions from the dorsal striatum (DS) to aversive learning, despite its well-established role in stimulus-response learning. Here, we review studies exploring the role of DS in aversive learning, including different roles for the dorsomedial and dorsolateral striatum in Pavlovian fear conditioning as well as innate and inhibitory avoidance (IA) behaviors. We outline how future investigation might determine specific contributions from DS subregions, cell types, and connections that contribute to aversive behavior.https://www.frontiersin.org/articles/10.3389/fncel.2021.634493/fulldorsal striatumfear conditioninginhibitory avoidanceaversionthreat |
spellingShingle | Adrien T. Stanley Pellegrino Lippiello David Sulzer David Sulzer Maria Concetta Miniaci Roles for the Dorsal Striatum in Aversive Behavior Frontiers in Cellular Neuroscience dorsal striatum fear conditioning inhibitory avoidance aversion threat |
title | Roles for the Dorsal Striatum in Aversive Behavior |
title_full | Roles for the Dorsal Striatum in Aversive Behavior |
title_fullStr | Roles for the Dorsal Striatum in Aversive Behavior |
title_full_unstemmed | Roles for the Dorsal Striatum in Aversive Behavior |
title_short | Roles for the Dorsal Striatum in Aversive Behavior |
title_sort | roles for the dorsal striatum in aversive behavior |
topic | dorsal striatum fear conditioning inhibitory avoidance aversion threat |
url | https://www.frontiersin.org/articles/10.3389/fncel.2021.634493/full |
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