Roles for the Dorsal Striatum in Aversive Behavior

The ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum. Rela...

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Main Authors: Adrien T. Stanley, Pellegrino Lippiello, David Sulzer, Maria Concetta Miniaci
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.634493/full
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author Adrien T. Stanley
Pellegrino Lippiello
David Sulzer
David Sulzer
Maria Concetta Miniaci
author_facet Adrien T. Stanley
Pellegrino Lippiello
David Sulzer
David Sulzer
Maria Concetta Miniaci
author_sort Adrien T. Stanley
collection DOAJ
description The ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum. Relatively little attention has been paid to contributions from the dorsal striatum (DS) to aversive learning, despite its well-established role in stimulus-response learning. Here, we review studies exploring the role of DS in aversive learning, including different roles for the dorsomedial and dorsolateral striatum in Pavlovian fear conditioning as well as innate and inhibitory avoidance (IA) behaviors. We outline how future investigation might determine specific contributions from DS subregions, cell types, and connections that contribute to aversive behavior.
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spelling doaj.art-bee8b933cf9642738a9253a52b8779002022-12-21T22:43:20ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-02-011510.3389/fncel.2021.634493634493Roles for the Dorsal Striatum in Aversive BehaviorAdrien T. Stanley0Pellegrino Lippiello1David Sulzer2David Sulzer3Maria Concetta Miniaci4Departments of Biology and Psychiatry, Columbia University, New York, NY, United StatesDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, ItalyDepartments of Psychiatry, Neurology, and Pharmacology, Columbia University Medical Center, New York, NY, United StatesDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United StatesDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, ItalyThe ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum. Relatively little attention has been paid to contributions from the dorsal striatum (DS) to aversive learning, despite its well-established role in stimulus-response learning. Here, we review studies exploring the role of DS in aversive learning, including different roles for the dorsomedial and dorsolateral striatum in Pavlovian fear conditioning as well as innate and inhibitory avoidance (IA) behaviors. We outline how future investigation might determine specific contributions from DS subregions, cell types, and connections that contribute to aversive behavior.https://www.frontiersin.org/articles/10.3389/fncel.2021.634493/fulldorsal striatumfear conditioninginhibitory avoidanceaversionthreat
spellingShingle Adrien T. Stanley
Pellegrino Lippiello
David Sulzer
David Sulzer
Maria Concetta Miniaci
Roles for the Dorsal Striatum in Aversive Behavior
Frontiers in Cellular Neuroscience
dorsal striatum
fear conditioning
inhibitory avoidance
aversion
threat
title Roles for the Dorsal Striatum in Aversive Behavior
title_full Roles for the Dorsal Striatum in Aversive Behavior
title_fullStr Roles for the Dorsal Striatum in Aversive Behavior
title_full_unstemmed Roles for the Dorsal Striatum in Aversive Behavior
title_short Roles for the Dorsal Striatum in Aversive Behavior
title_sort roles for the dorsal striatum in aversive behavior
topic dorsal striatum
fear conditioning
inhibitory avoidance
aversion
threat
url https://www.frontiersin.org/articles/10.3389/fncel.2021.634493/full
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AT mariaconcettaminiaci rolesforthedorsalstriatuminaversivebehavior