Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome
Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS). The plasma channels of voltage-gated sodium channels (VGSCs), voltage-gated calcium channels (VGCCs) and trans...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2020-08-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191160.pdf |
| _version_ | 1827390477295419392 |
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| author | LAN Fei, LIU Tai-yang, YANG Jie |
| author_facet | LAN Fei, LIU Tai-yang, YANG Jie |
| author_sort | LAN Fei, LIU Tai-yang, YANG Jie |
| collection | DOAJ |
| description | Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS). The plasma channels of voltage-gated sodium channels (VGSCs), voltage-gated calcium channels (VGCCs) and transient receptor potential channels (TRPs) are involved in IBS gastrointestinal motility and visceral hypersensitivity to varying degrees. They are key pathophysiological and therapeutic targets for regulating gastrointestinal motility and visceral hypersensitivity. |
| first_indexed | 2024-03-08T16:53:18Z |
| format | Article |
| id | doaj.art-bee915e52d97443daae9213b2565f985 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:53:18Z |
| publishDate | 2020-08-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-bee915e52d97443daae9213b2565f9852024-01-05T03:17:00ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252020-08-0140811351139Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndromeLAN Fei, LIU Tai-yang, YANG Jie0Department of Gastroenterology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaIon channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS). The plasma channels of voltage-gated sodium channels (VGSCs), voltage-gated calcium channels (VGCCs) and transient receptor potential channels (TRPs) are involved in IBS gastrointestinal motility and visceral hypersensitivity to varying degrees. They are key pathophysiological and therapeutic targets for regulating gastrointestinal motility and visceral hypersensitivity.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191160.pdfirritable bowel syndrome|pathogenesis|ion channels |
| spellingShingle | LAN Fei, LIU Tai-yang, YANG Jie Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome Jichu yixue yu linchuang irritable bowel syndrome|pathogenesis|ion channels |
| title | Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome |
| title_full | Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome |
| title_fullStr | Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome |
| title_full_unstemmed | Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome |
| title_short | Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome |
| title_sort | advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome |
| topic | irritable bowel syndrome|pathogenesis|ion channels |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a191160.pdf |
| work_keys_str_mv | AT lanfeiliutaiyangyangjie advancesintheroleofintestinalionchannelsinthepathogenesisofirritablebowelsyndrome |