Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering
Tremendous advances in tissue engineering and regenerative medicine have revealed the potential of fabricating biomaterials to solve the dilemma of bone and articular defects by promoting osteochondral and cartilage regeneration. Three-dimensional (3D) bioprinting is an innovative fabrication techno...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.865770/full |
| _version_ | 1828365730406465536 |
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| author | Zhimin Yang Zhimin Yang Ping Yi Zhongyue Liu Zhongyue Liu Wenchao Zhang Wenchao Zhang Lin Mei Lin Mei Chengyao Feng Chengyao Feng Chao Tu Chao Tu Zhihong Li Zhihong Li |
| author_facet | Zhimin Yang Zhimin Yang Ping Yi Zhongyue Liu Zhongyue Liu Wenchao Zhang Wenchao Zhang Lin Mei Lin Mei Chengyao Feng Chengyao Feng Chao Tu Chao Tu Zhihong Li Zhihong Li |
| author_sort | Zhimin Yang |
| collection | DOAJ |
| description | Tremendous advances in tissue engineering and regenerative medicine have revealed the potential of fabricating biomaterials to solve the dilemma of bone and articular defects by promoting osteochondral and cartilage regeneration. Three-dimensional (3D) bioprinting is an innovative fabrication technology to precisely distribute the cell-laden bioink for the construction of artificial tissues, demonstrating great prospect in bone and joint construction areas. With well controllable printability, biocompatibility, biodegradability, and mechanical properties, hydrogels have been emerging as an attractive 3D bioprinting material, which provides a favorable biomimetic microenvironment for cell adhesion, orientation, migration, proliferation, and differentiation. Stem cell-based therapy has been known as a promising approach in regenerative medicine; however, limitations arise from the uncontrollable proliferation, migration, and differentiation of the stem cells and fortunately could be improved after stem cells were encapsulated in the hydrogel. In this review, our focus was centered on the characterization and application of stem cell-laden hydrogel-based 3D bioprinting for bone and cartilage tissue engineering. We not only highlighted the effect of various kinds of hydrogels, stem cells, inorganic particles, and growth factors on chondrogenesis and osteogenesis but also outlined the relationship between biophysical properties like biocompatibility, biodegradability, osteoinductivity, and the regeneration of bone and cartilage. This study was invented to discuss the challenge we have been encountering, the recent progress we have achieved, and the future perspective we have proposed for in this field. |
| first_indexed | 2024-04-14T05:35:03Z |
| format | Article |
| id | doaj.art-beea1b93f86d4a19a55486720aa3ee17 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-14T05:35:03Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-beea1b93f86d4a19a55486720aa3ee172022-12-22T02:09:40ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.865770865770Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue EngineeringZhimin Yang0Zhimin Yang1Ping Yi2Zhongyue Liu3Zhongyue Liu4Wenchao Zhang5Wenchao Zhang6Lin Mei7Lin Mei8Chengyao Feng9Chengyao Feng10Chao Tu11Chao Tu12Zhihong Li13Zhihong Li14Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaTremendous advances in tissue engineering and regenerative medicine have revealed the potential of fabricating biomaterials to solve the dilemma of bone and articular defects by promoting osteochondral and cartilage regeneration. Three-dimensional (3D) bioprinting is an innovative fabrication technology to precisely distribute the cell-laden bioink for the construction of artificial tissues, demonstrating great prospect in bone and joint construction areas. With well controllable printability, biocompatibility, biodegradability, and mechanical properties, hydrogels have been emerging as an attractive 3D bioprinting material, which provides a favorable biomimetic microenvironment for cell adhesion, orientation, migration, proliferation, and differentiation. Stem cell-based therapy has been known as a promising approach in regenerative medicine; however, limitations arise from the uncontrollable proliferation, migration, and differentiation of the stem cells and fortunately could be improved after stem cells were encapsulated in the hydrogel. In this review, our focus was centered on the characterization and application of stem cell-laden hydrogel-based 3D bioprinting for bone and cartilage tissue engineering. We not only highlighted the effect of various kinds of hydrogels, stem cells, inorganic particles, and growth factors on chondrogenesis and osteogenesis but also outlined the relationship between biophysical properties like biocompatibility, biodegradability, osteoinductivity, and the regeneration of bone and cartilage. This study was invented to discuss the challenge we have been encountering, the recent progress we have achieved, and the future perspective we have proposed for in this field.https://www.frontiersin.org/articles/10.3389/fbioe.2022.865770/fullstem cellhydrogel3D bioprintingbonecartilage |
| spellingShingle | Zhimin Yang Zhimin Yang Ping Yi Zhongyue Liu Zhongyue Liu Wenchao Zhang Wenchao Zhang Lin Mei Lin Mei Chengyao Feng Chengyao Feng Chao Tu Chao Tu Zhihong Li Zhihong Li Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering Frontiers in Bioengineering and Biotechnology stem cell hydrogel 3D bioprinting bone cartilage |
| title | Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering |
| title_full | Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering |
| title_fullStr | Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering |
| title_full_unstemmed | Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering |
| title_short | Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering |
| title_sort | stem cell laden hydrogel based 3d bioprinting for bone and cartilage tissue engineering |
| topic | stem cell hydrogel 3D bioprinting bone cartilage |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.865770/full |
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