Over-Expression of LEDGF/p75 in HEp-2 Cells Enhances Autoimmune IgG Response in Patients with Benign Prostatic Hyperplasia—A Novel Diagnostic Approach with Therapeutic Consequence?

Over-Expression of LEDGF/p75 in HEp-2 Cells Enhances Autoimmune IgG Response in Patients with Benign Prostatic Hyperplasia—A Novel Diagnostic Approach with Therapeutic Consequence?

Lens epithelium-derived growth factor splice variant of 75 kDa (LEDGF/p75) is an autoantigen over-expressed in solid tumors and acts as a stress-related transcriptional co-activator. Participation of autoimmune responses in the pathophysiology of benign prostatic hyperplasia (PBH) and a correspondin...

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Bibliographic Details
Main Authors: Victoria Liedtke, Laura Rose, Rico Hiemann, Abdullah Nasser, Stefan Rödiger, Alena Bonaventura, Laura Winkler, Mandy Sowa, Michael Stöckle, Peter Schierack, Kerstin Junker, Dirk Roggenbuck
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
LEDGF/p75
autoimmunity
CRISPR/Cas9
dsDNA
mDNA
Online Access:https://www.mdpi.com/1422-0067/24/7/6166

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