A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV
<p>Abstract</p> <p>Background</p> <p>Type I Interferons (IFNs) are well known cytokines which exert antiviral activity, antitumor activity and immunomodulatory effects. Single-nucleotide polymorphisms (SNP) and deletions in the gene coding for <it>IFNA2 </it>...
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| Format: | Article |
| Language: | English |
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BMC
2008-12-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/9/80 |
| _version_ | 1818247305458876416 |
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| author | Tomiuk Jürgen Song Le H de Messias-Reason Iara Tena-Tomás Cristina Kemsner Peter G Kun Jürgen FJ |
| author_facet | Tomiuk Jürgen Song Le H de Messias-Reason Iara Tena-Tomás Cristina Kemsner Peter G Kun Jürgen FJ |
| author_sort | Tomiuk Jürgen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Type I Interferons (IFNs) are well known cytokines which exert antiviral activity, antitumor activity and immunomodulatory effects. Single-nucleotide polymorphisms (SNP) and deletions in the gene coding for <it>IFNA2 </it>have been shown to influence the level of expression <it>in vitro</it>. The indel polymorphism -305_-300delAACTTT showed the strongest effect <it>in vitro</it>. To analyse the worldwide distribution of this polymorphism we analyzed five different populations (586 Vietnamese, 199 Central Africans, 265 Brazilians, 108 Kaingang and 98 Guarani). To investigate a possible association with susceptibility to infectious diseases we determined the polymorphism in malaria patients suffering either mild or severe malaria and in a cohort of hepatitis C virus infected individuals.</p> <p>Results</p> <p>We could detect the indel polymorphism in all populations analysed. There was no association with this polymorphism and the outcome of malaria but we found an increase of this indel polymorphism in hepatitis C virus positive individuals compared to healthy controls (p = 0.014).</p> <p>Conclusion</p> <p>Polymorphisms in genes involved in the interferon pathway have been implicated in the resistance or susceptibility against cerebral malaria and HBV. Here we show that an indel polymorphism, which mediates a disadvantageous effect in HBV patients, may also play a disadvantageous role in HCV infections stressing the importance of a fully functional interferon pathway.</p> |
| first_indexed | 2024-12-12T15:02:36Z |
| format | Article |
| id | doaj.art-beebd9c27d894070a504fe1e807af892 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-12-12T15:02:36Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-beebd9c27d894070a504fe1e807af8922022-12-22T00:20:47ZengBMCBMC Genetics1471-21562008-12-01918010.1186/1471-2156-9-80A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCVTomiuk JürgenSong Le Hde Messias-Reason IaraTena-Tomás CristinaKemsner Peter GKun Jürgen FJ<p>Abstract</p> <p>Background</p> <p>Type I Interferons (IFNs) are well known cytokines which exert antiviral activity, antitumor activity and immunomodulatory effects. Single-nucleotide polymorphisms (SNP) and deletions in the gene coding for <it>IFNA2 </it>have been shown to influence the level of expression <it>in vitro</it>. The indel polymorphism -305_-300delAACTTT showed the strongest effect <it>in vitro</it>. To analyse the worldwide distribution of this polymorphism we analyzed five different populations (586 Vietnamese, 199 Central Africans, 265 Brazilians, 108 Kaingang and 98 Guarani). To investigate a possible association with susceptibility to infectious diseases we determined the polymorphism in malaria patients suffering either mild or severe malaria and in a cohort of hepatitis C virus infected individuals.</p> <p>Results</p> <p>We could detect the indel polymorphism in all populations analysed. There was no association with this polymorphism and the outcome of malaria but we found an increase of this indel polymorphism in hepatitis C virus positive individuals compared to healthy controls (p = 0.014).</p> <p>Conclusion</p> <p>Polymorphisms in genes involved in the interferon pathway have been implicated in the resistance or susceptibility against cerebral malaria and HBV. Here we show that an indel polymorphism, which mediates a disadvantageous effect in HBV patients, may also play a disadvantageous role in HCV infections stressing the importance of a fully functional interferon pathway.</p>http://www.biomedcentral.com/1471-2156/9/80 |
| spellingShingle | Tomiuk Jürgen Song Le H de Messias-Reason Iara Tena-Tomás Cristina Kemsner Peter G Kun Jürgen FJ A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV BMC Genetics |
| title | A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV |
| title_full | A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV |
| title_fullStr | A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV |
| title_full_unstemmed | A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV |
| title_short | A globally occurring indel polymorphism in the promoter of the <it>IFNA2 </it>gene is not associated with severity of malaria but with the positivity rate of HCV |
| title_sort | globally occurring indel polymorphism in the promoter of the it ifna2 it gene is not associated with severity of malaria but with the positivity rate of hcv |
| url | http://www.biomedcentral.com/1471-2156/9/80 |
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