Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions
<i>Myrtus communis</i> L. essential oil (EO), mainly composed of myrtenyl acetate (30.6%), linalool (14.9%), α-pinene (11.10%) and 1,8-cineole or eucalyptol (9.9%), was microencapsulated with maltodextrin by emulsification and spray-drying, reaching a yield and efficiency of 43.7 and 48....
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/5/1566 |
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| author | Rim Ben Mansour Raja Serairi Beji Hanen Wasli Sami Zekri Riadh Ksouri Wided Megdiche-Ksouri Susana M. Cardoso |
| author_facet | Rim Ben Mansour Raja Serairi Beji Hanen Wasli Sami Zekri Riadh Ksouri Wided Megdiche-Ksouri Susana M. Cardoso |
| author_sort | Rim Ben Mansour |
| collection | DOAJ |
| description | <i>Myrtus communis</i> L. essential oil (EO), mainly composed of myrtenyl acetate (30.6%), linalool (14.9%), α-pinene (11.10%) and 1,8-cineole or eucalyptol (9.9%), was microencapsulated with maltodextrin by emulsification and spray-drying, reaching a yield and efficiency of 43.7 and 48.7%, respectively. The microencapsulated myrtle EO (MMEO) was then evaluated regarding its gastroprotective activity in a model of ethanol/HCl-induced acute gastric ulcer in Wistar rats. Pretreatment with MMEO induced a remarkable inhibition of gastric lesions and acidity, correlated to high healing and protection percentages. Moreover, it exerted a potent anti-inflammatory effect on the gastric mucosa, counteracting EtOH-induced gastric lipoperoxidation and preventing the depletion of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Taken together, the gastroprotective action of encapsulated MMEO may be multi-factorial, and ascribable, at least in parts, to its anti-inflammatory and antioxidant properties. |
| first_indexed | 2024-03-09T20:30:26Z |
| format | Article |
| id | doaj.art-beec6c3117bf4dd1af2d97c26138c7b1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T20:30:26Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-beec6c3117bf4dd1af2d97c26138c7b12023-11-23T23:26:23ZengMDPI AGMolecules1420-30492022-02-01275156610.3390/molecules27051566Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric LesionsRim Ben Mansour0Raja Serairi Beji1Hanen Wasli2Sami Zekri3Riadh Ksouri4Wided Megdiche-Ksouri5Susana M. Cardoso6Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, TunisiaUSCR, Unité de Services Communs pour la Recherche en Microscopie Electronique à Transmission, Faculté de Médecine de Tunis, Tunis 1029, TunisiaLaboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, TunisiaLaboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, TunisiaLAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal<i>Myrtus communis</i> L. essential oil (EO), mainly composed of myrtenyl acetate (30.6%), linalool (14.9%), α-pinene (11.10%) and 1,8-cineole or eucalyptol (9.9%), was microencapsulated with maltodextrin by emulsification and spray-drying, reaching a yield and efficiency of 43.7 and 48.7%, respectively. The microencapsulated myrtle EO (MMEO) was then evaluated regarding its gastroprotective activity in a model of ethanol/HCl-induced acute gastric ulcer in Wistar rats. Pretreatment with MMEO induced a remarkable inhibition of gastric lesions and acidity, correlated to high healing and protection percentages. Moreover, it exerted a potent anti-inflammatory effect on the gastric mucosa, counteracting EtOH-induced gastric lipoperoxidation and preventing the depletion of the antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Taken together, the gastroprotective action of encapsulated MMEO may be multi-factorial, and ascribable, at least in parts, to its anti-inflammatory and antioxidant properties.https://www.mdpi.com/1420-3049/27/5/1566<i>Myrtus communis</i>essential oilmicroencapsulationspray dryinggastroprotective activityanti-inflammatory |
| spellingShingle | Rim Ben Mansour Raja Serairi Beji Hanen Wasli Sami Zekri Riadh Ksouri Wided Megdiche-Ksouri Susana M. Cardoso Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions Molecules <i>Myrtus communis</i> essential oil microencapsulation spray drying gastroprotective activity anti-inflammatory |
| title | Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions |
| title_full | Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions |
| title_fullStr | Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions |
| title_full_unstemmed | Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions |
| title_short | Gastroprotective Effect of Microencapsulated <i>Myrtus communis</i> Essential Oil against Ethanol/HCl-Induced Acute Gastric Lesions |
| title_sort | gastroprotective effect of microencapsulated i myrtus communis i essential oil against ethanol hcl induced acute gastric lesions |
| topic | <i>Myrtus communis</i> essential oil microencapsulation spray drying gastroprotective activity anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/27/5/1566 |
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