Cinnamides Target <i>Leishmania amazonensis</i> Arginase Selectively

Cinnamides Target <i>Leishmania amazonensis</i> Arginase Selectively

Caffeic acid and related natural compounds were previously described as <i>Leishmania amazonensis</i> arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this study, we tested cinnamides that were previously synthesized to target human arginase. The compound caffeic...

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Bibliographic Details
Main Authors: Edson Roberto da Silva, Júlio Abel Alfredo dos Santos Simone Come, Simone Brogi, Vincenzo Calderone, Giulia Chemi, Giuseppe Campiani, Trícia Maria Ferrreira de Sousa Oliveira, Thanh-Nhat Pham, Marc Pudlo, Corine Girard, Claudia do Carmo Maquiaveli
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
arginase
polyamines
<i>Leishmania</i>
Online Access:https://www.mdpi.com/1420-3049/25/22/5271

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