P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY
Purpose/Background/Objectives: Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods: We measured carotid intima-m...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-12-01
|
| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930356/view |
| _version_ | 1811252586921066496 |
|---|---|
| author | Nikolaos Ioakeimidis Charalambos Vlachopoulos Athanasios Angelis Dimitrios Terentes- Printzios Christos Georgakopoulos Konstantinos Aznaouridis Iosif Koutagiar John Skoumas Skliros Dimitrios Tousoulis |
| author_facet | Nikolaos Ioakeimidis Charalambos Vlachopoulos Athanasios Angelis Dimitrios Terentes- Printzios Christos Georgakopoulos Konstantinos Aznaouridis Iosif Koutagiar John Skoumas Skliros Dimitrios Tousoulis |
| author_sort | Nikolaos Ioakeimidis |
| collection | DOAJ |
| description | Purpose/Background/Objectives: Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy.
Methods: We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57±9 years). Lipid parameters and total testosterone were measured in all patients.
Results: 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL < 100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl).
Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot).
Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3).
Conclusions: Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. |
| first_indexed | 2024-04-12T16:36:57Z |
| format | Article |
| id | doaj.art-bef5bc80a3af4803b8f8c373e6e8c556 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-12T16:36:57Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-bef5bc80a3af4803b8f8c373e6e8c5562022-12-22T03:24:57ZengBMCArtery Research1876-44012017-12-012010.1016/j.artres.2017.10.194P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPYNikolaos IoakeimidisCharalambos VlachopoulosAthanasios AngelisDimitrios Terentes- PrintziosChristos GeorgakopoulosKonstantinos AznaouridisIosif KoutagiarJohn SkoumasSklirosDimitrios TousoulisPurpose/Background/Objectives: Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods: We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57±9 years). Lipid parameters and total testosterone were measured in all patients. Results: 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL < 100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions: Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired.https://www.atlantis-press.com/article/125930356/view |
| spellingShingle | Nikolaos Ioakeimidis Charalambos Vlachopoulos Athanasios Angelis Dimitrios Terentes- Printzios Christos Georgakopoulos Konstantinos Aznaouridis Iosif Koutagiar John Skoumas Skliros Dimitrios Tousoulis P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY Artery Research |
| title | P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY |
| title_full | P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY |
| title_fullStr | P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY |
| title_full_unstemmed | P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY |
| title_short | P193 CAROTID ATHEROSCLEROSIS, AORTIC STIFFNESS AND PENILE VASCULAR DAMAGE IN PATIENTS WITH ERECTILE DYSFUNCTION: RELATION TO LOW DENSITY LIPOPROTEIN LEVELS AND STATIN THERAPY |
| title_sort | p193 carotid atherosclerosis aortic stiffness and penile vascular damage in patients with erectile dysfunction relation to low density lipoprotein levels and statin therapy |
| url | https://www.atlantis-press.com/article/125930356/view |
| work_keys_str_mv | AT nikolaosioakeimidis p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT charalambosvlachopoulos p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT athanasiosangelis p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT dimitriosterentesprintzios p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT christosgeorgakopoulos p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT konstantinosaznaouridis p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT iosifkoutagiar p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT johnskoumas p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT skliros p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy AT dimitriostousoulis p193carotidatherosclerosisaorticstiffnessandpenilevasculardamageinpatientswitherectiledysfunctionrelationtolowdensitylipoproteinlevelsandstatintherapy |