Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model
Objectives: The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. Methods: The antibacterial activity of ceftaroline was compared w...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716520300278 |
| _version_ | 1818914827945377792 |
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| author | Sinan Mermer Tuncer Turhan Elif Bolat Sohret Aydemir Tansu Yamazhan Husnu Pullukcu Bilgin Arda Hilal Sipahi Sercan Ulusoy Oguz Resat Sipahi |
| author_facet | Sinan Mermer Tuncer Turhan Elif Bolat Sohret Aydemir Tansu Yamazhan Husnu Pullukcu Bilgin Arda Hilal Sipahi Sercan Ulusoy Oguz Resat Sipahi |
| author_sort | Sinan Mermer |
| collection | DOAJ |
| description | Objectives: The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. Methods: The antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24 h and 73 h after the first antibiotic dose. Furthermore, in vitro time–kill data were investigated at 0, 2, 4, 6, 8, 12 and 24 h in sterile human serum. Results: The difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24 h and 73 h after the first antibiotic dose (P < 0.05). At the end of the experiment, there was a significant difference in survival between both the ceftaroline-treated group and the vancomycin-treated group versus the control group, but not between the two treatment groups. Conclusion: These results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model. |
| first_indexed | 2024-12-19T23:52:35Z |
| format | Article |
| id | doaj.art-bef803ec22a5410d8c582a66dd0f1be5 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-12-19T23:52:35Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-bef803ec22a5410d8c582a66dd0f1be52022-12-21T20:01:06ZengElsevierJournal of Global Antimicrobial Resistance2213-71652020-09-0122147151Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis modelSinan Mermer0Tuncer Turhan1Elif Bolat2Sohret Aydemir3Tansu Yamazhan4Husnu Pullukcu5Bilgin Arda6Hilal Sipahi7Sercan Ulusoy8Oguz Resat Sipahi9Cine State Hospital, Aydin, Turkey; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, TurkeyDepartment of Neurosurgery, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Neurosurgery, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Ege University, Izmir, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, TurkeyBornova Health Directorate, Izmir, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey; Corresponding author.Objectives: The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. Methods: The antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24 h and 73 h after the first antibiotic dose. Furthermore, in vitro time–kill data were investigated at 0, 2, 4, 6, 8, 12 and 24 h in sterile human serum. Results: The difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24 h and 73 h after the first antibiotic dose (P < 0.05). At the end of the experiment, there was a significant difference in survival between both the ceftaroline-treated group and the vancomycin-treated group versus the control group, but not between the two treatment groups. Conclusion: These results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model.http://www.sciencedirect.com/science/article/pii/S2213716520300278Nosocomial meningitisMethicillin-resistant staphylococciCentral nervous system infectionGlycopeptidesAnimal modelPharmacokinetics |
| spellingShingle | Sinan Mermer Tuncer Turhan Elif Bolat Sohret Aydemir Tansu Yamazhan Husnu Pullukcu Bilgin Arda Hilal Sipahi Sercan Ulusoy Oguz Resat Sipahi Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model Journal of Global Antimicrobial Resistance Nosocomial meningitis Methicillin-resistant staphylococci Central nervous system infection Glycopeptides Animal model Pharmacokinetics |
| title | Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model |
| title_full | Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model |
| title_fullStr | Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model |
| title_full_unstemmed | Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model |
| title_short | Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model |
| title_sort | ceftaroline versus vancomycin in the treatment of methicillin resistant staphylococcus aureus mrsa in an experimental mrsa meningitis model |
| topic | Nosocomial meningitis Methicillin-resistant staphylococci Central nervous system infection Glycopeptides Animal model Pharmacokinetics |
| url | http://www.sciencedirect.com/science/article/pii/S2213716520300278 |
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