Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis
Background: Acute pancreatitis is a disease which has many etiologies. Each etiology seems to affect the pancreatic acinar cell in some way that results in premature activation and retention of potent proteolytic enzymes. Low molecular weight heparin (LMWH) is known to reduce the release the cytokin...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-09-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/46834 |
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| author | Rojaramani Kumbha Sobharani Bathena Hari Babu Mekala Anand Venkat Vineeth Amavasya |
| author_facet | Rojaramani Kumbha Sobharani Bathena Hari Babu Mekala Anand Venkat Vineeth Amavasya |
| author_sort | Rojaramani Kumbha |
| collection | DOAJ |
| description | Background: Acute pancreatitis is a disease which has many etiologies. Each etiology seems to affect the pancreatic acinar cell in some way that results in premature activation and retention of potent proteolytic enzymes. Low molecular weight heparin (LMWH) is known to reduce the release the cytokines and inflammatory mediators and result in the improvement of microcirculation of pancreas.
Aims and Objectives: The aim of the study was to determine the efficacy of LMWH therapy in patients with severe acute pancreatitis (SAP).
Materials and Methods: Our research comprised of 100 patients who were randomly assigned to one of two groups: Conventional treatment for SAP (n=50) or conventional therapy +LMWH (n=50). All the data were statistically analyzed in SPSS software 15.0.
Results: In both groups, the death rate was 2%, and 49 patients in each group were cured of their disease after therapy. The minimum hospital stay in the heparin group is 5 days, while the highest hospital stay is 17 days. In the conventional group, the minimum hospital stay is 4 days, and the maximum hospital stay is 21 days.
Conclusion: For the treatment of SAP, LMWH is a straightforward, safe, effective, and cost- efficient technique. It is suitable for usage in any hospital. There was no significant improvement in the impact of traditional SAP therapy with LMWH, nor was there any reduction in SAP mortality. Renal problems were more prevalent among the patients than sepsis-related complications among the conventional group. It was, however, statistically insignificant. |
| first_indexed | 2024-04-14T06:43:16Z |
| format | Article |
| id | doaj.art-bef933f0daef45289cfa3292cba04685 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-14T06:43:16Z |
| publishDate | 2022-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-bef933f0daef45289cfa3292cba046852022-12-22T02:07:15ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-09-01139109116https://doi.org/10.3126/ajms.v13i9.46834Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitisRojaramani Kumbha 0https://orcid.org/0000-0003-2329-7209Sobharani Bathena 1Hari Babu Mekala Anand 2Venkat Vineeth Amavasya 3Associate Professor, Department of General Surgery, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh, India Professor and Head, Department of General Surgery, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh, IndiaAssistant Professor, Department of General Surgery, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh, IndiaFinal Year Postgraduate, Department of General Surgery, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh, IndiaBackground: Acute pancreatitis is a disease which has many etiologies. Each etiology seems to affect the pancreatic acinar cell in some way that results in premature activation and retention of potent proteolytic enzymes. Low molecular weight heparin (LMWH) is known to reduce the release the cytokines and inflammatory mediators and result in the improvement of microcirculation of pancreas. Aims and Objectives: The aim of the study was to determine the efficacy of LMWH therapy in patients with severe acute pancreatitis (SAP). Materials and Methods: Our research comprised of 100 patients who were randomly assigned to one of two groups: Conventional treatment for SAP (n=50) or conventional therapy +LMWH (n=50). All the data were statistically analyzed in SPSS software 15.0. Results: In both groups, the death rate was 2%, and 49 patients in each group were cured of their disease after therapy. The minimum hospital stay in the heparin group is 5 days, while the highest hospital stay is 17 days. In the conventional group, the minimum hospital stay is 4 days, and the maximum hospital stay is 21 days. Conclusion: For the treatment of SAP, LMWH is a straightforward, safe, effective, and cost- efficient technique. It is suitable for usage in any hospital. There was no significant improvement in the impact of traditional SAP therapy with LMWH, nor was there any reduction in SAP mortality. Renal problems were more prevalent among the patients than sepsis-related complications among the conventional group. It was, however, statistically insignificant.https://www.nepjol.info/index.php/AJMS/article/view/46834acute pancreatitis; low molecular weight of heparin; proteolytic enzymes |
| spellingShingle | Rojaramani Kumbha Sobharani Bathena Hari Babu Mekala Anand Venkat Vineeth Amavasya Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis Asian Journal of Medical Sciences acute pancreatitis; low molecular weight of heparin; proteolytic enzymes |
| title | Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis |
| title_full | Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis |
| title_fullStr | Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis |
| title_full_unstemmed | Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis |
| title_short | Study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis |
| title_sort | study of role of low molecular weight heparin in conjunction with conventional therapy in severe acute pancreatitis |
| topic | acute pancreatitis; low molecular weight of heparin; proteolytic enzymes |
| url | https://www.nepjol.info/index.php/AJMS/article/view/46834 |
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