New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i>
Four new peptides were isolated from the culture broths of the marine-derived fungi <i>Aspergillus</i> <i>allahabadii</i> and <i>A.</i> ochraceopetaliformis. Based on the results of chemical and spectroscopic analyses, two compounds (<b>1</b> and <b...
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| Format: | Article |
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MDPI AG
2019-08-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/9/488 |
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| author | Ji-Yeon Hwang Jung-Ho Lee Sung Chul Park Jayho Lee Dong-Chan Oh Ki-Bong Oh Jongheon Shin |
| author_facet | Ji-Yeon Hwang Jung-Ho Lee Sung Chul Park Jayho Lee Dong-Chan Oh Ki-Bong Oh Jongheon Shin |
| author_sort | Ji-Yeon Hwang |
| collection | DOAJ |
| description | Four new peptides were isolated from the culture broths of the marine-derived fungi <i>Aspergillus</i> <i>allahabadii</i> and <i>A.</i> ochraceopetaliformis. Based on the results of chemical and spectroscopic analyses, two compounds (<b>1</b> and <b>2</b>) from <i>A.</i> <i>allahabadii</i><i> </i>were determined to be cyclopentapeptides, while those from <i>A.</i> ochraceopetaliformis were a structurally-related cyclodepsihexapeptide (<b>3</b>) and its linear analog (<b>4</b>). In addition to the presence of a D-amino acid residue, the almost reversed sequence of peptides in <b>3</b> and <b>4</b>, relative to those of the <b>1</b> and <b>2</b>, is notable. These new compounds exhibited moderate inhibition against the enzyme sortase A as well as a weak inhibition against isocitrate lyase (<b>2</b>). |
| first_indexed | 2024-04-11T18:24:29Z |
| format | Article |
| id | doaj.art-befacad5333345aa99836d17ea8181d5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T18:24:29Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-befacad5333345aa99836d17ea8181d52022-12-22T04:09:39ZengMDPI AGMarine Drugs1660-33972019-08-0117948810.3390/md17090488md17090488New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i>Ji-Yeon Hwang0Jung-Ho Lee1Sung Chul Park2Jayho Lee3Dong-Chan Oh4Ki-Bong Oh5Jongheon Shin6Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaDepartment of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaDepartment of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, KoreaNatural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, KoreaFour new peptides were isolated from the culture broths of the marine-derived fungi <i>Aspergillus</i> <i>allahabadii</i> and <i>A.</i> ochraceopetaliformis. Based on the results of chemical and spectroscopic analyses, two compounds (<b>1</b> and <b>2</b>) from <i>A.</i> <i>allahabadii</i><i> </i>were determined to be cyclopentapeptides, while those from <i>A.</i> ochraceopetaliformis were a structurally-related cyclodepsihexapeptide (<b>3</b>) and its linear analog (<b>4</b>). In addition to the presence of a D-amino acid residue, the almost reversed sequence of peptides in <b>3</b> and <b>4</b>, relative to those of the <b>1</b> and <b>2</b>, is notable. These new compounds exhibited moderate inhibition against the enzyme sortase A as well as a weak inhibition against isocitrate lyase (<b>2</b>).https://www.mdpi.com/1660-3397/17/9/488peptidesmarine-derived fungi<i>Aspergillus allahabadii</i><i>Aspergillus ochraceopetaliformis</i>isocitrate lyasesortase A |
| spellingShingle | Ji-Yeon Hwang Jung-Ho Lee Sung Chul Park Jayho Lee Dong-Chan Oh Ki-Bong Oh Jongheon Shin New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i> Marine Drugs peptides marine-derived fungi <i>Aspergillus allahabadii</i> <i>Aspergillus ochraceopetaliformis</i> isocitrate lyase sortase A |
| title | New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i> |
| title_full | New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i> |
| title_fullStr | New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i> |
| title_full_unstemmed | New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i> |
| title_short | New Peptides from The Marine-Derived Fungi <i>Aspergillus allahabadii</i> and <i>Aspergillus ochraceopetaliformis</i> |
| title_sort | new peptides from the marine derived fungi i aspergillus allahabadii i and i aspergillus ochraceopetaliformis i |
| topic | peptides marine-derived fungi <i>Aspergillus allahabadii</i> <i>Aspergillus ochraceopetaliformis</i> isocitrate lyase sortase A |
| url | https://www.mdpi.com/1660-3397/17/9/488 |
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