Role of NRF2 in Colorectal Cancer Prevention and Treatment
Nuclear factor erythroid 2-related factor 2 (NRF2) is a basic leucine zipper protein that participates in a complex regulatory network in the body. The activation of NRF2 can prevent and treat colorectal cancer (CRC). A variety of natural compounds can activate NRF2 to inhibit oxidative stress and i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-12-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221105736 |
| _version_ | 1811186306095513600 |
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| author | Jiaxiang Li BS Dan Wang MS Yifei Liu MS Yanhong Zhou PHD |
| author_facet | Jiaxiang Li BS Dan Wang MS Yifei Liu MS Yanhong Zhou PHD |
| author_sort | Jiaxiang Li BS |
| collection | DOAJ |
| description | Nuclear factor erythroid 2-related factor 2 (NRF2) is a basic leucine zipper protein that participates in a complex regulatory network in the body. The activation of NRF2 can prevent and treat colorectal cancer (CRC). A variety of natural compounds can activate NRF2 to inhibit oxidative stress and inflammation to prevent the occurrence and development of CRC, inhibit the proliferation of CRC cells and induce their apoptosis. However, some studies have also shown that it also has negative effects on CRC, such as overexpression of NRF2 can promote the growth of colorectal tumors and increase the drug resistance of chemotherapeutic drugs such as 5-fluorouracil and oxaliplatin. Therefore, inhibition of NRF2 can also be helpful in the treatment of CRC. In this study, we analyze the current research progress of NRF2 in CRC from various aspects to provide new ideas for prevention and treatment based on the NRF2 signaling pathway in CRC. |
| first_indexed | 2024-04-11T13:44:26Z |
| format | Article |
| id | doaj.art-befad8694aa348d18449c8632aec405f |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-11T13:44:26Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-befad8694aa348d18449c8632aec405f2022-12-22T04:21:09ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-12-012110.1177/15330338221105736Role of NRF2 in Colorectal Cancer Prevention and TreatmentJiaxiang Li BS0Dan Wang MS1Yifei Liu MS2Yanhong Zhou PHD3 School of Pharmacy, Xianning Medical College, , Xianning, Hubei, China School of Pharmacy, Xianning Medical College, , Xianning, Hubei, China School of Stomatology and Ophthalmology, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, China School of Pharmacy, Xianning Medical College, , Xianning, Hubei, ChinaNuclear factor erythroid 2-related factor 2 (NRF2) is a basic leucine zipper protein that participates in a complex regulatory network in the body. The activation of NRF2 can prevent and treat colorectal cancer (CRC). A variety of natural compounds can activate NRF2 to inhibit oxidative stress and inflammation to prevent the occurrence and development of CRC, inhibit the proliferation of CRC cells and induce their apoptosis. However, some studies have also shown that it also has negative effects on CRC, such as overexpression of NRF2 can promote the growth of colorectal tumors and increase the drug resistance of chemotherapeutic drugs such as 5-fluorouracil and oxaliplatin. Therefore, inhibition of NRF2 can also be helpful in the treatment of CRC. In this study, we analyze the current research progress of NRF2 in CRC from various aspects to provide new ideas for prevention and treatment based on the NRF2 signaling pathway in CRC.https://doi.org/10.1177/15330338221105736 |
| spellingShingle | Jiaxiang Li BS Dan Wang MS Yifei Liu MS Yanhong Zhou PHD Role of NRF2 in Colorectal Cancer Prevention and Treatment Technology in Cancer Research & Treatment |
| title | Role of NRF2 in Colorectal Cancer Prevention and Treatment |
| title_full | Role of NRF2 in Colorectal Cancer Prevention and Treatment |
| title_fullStr | Role of NRF2 in Colorectal Cancer Prevention and Treatment |
| title_full_unstemmed | Role of NRF2 in Colorectal Cancer Prevention and Treatment |
| title_short | Role of NRF2 in Colorectal Cancer Prevention and Treatment |
| title_sort | role of nrf2 in colorectal cancer prevention and treatment |
| url | https://doi.org/10.1177/15330338221105736 |
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