Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy
An elevation of serum low-density lipoprotein cholesterol (LDL-C) levels has been associated with endothelial dysfunction in statin naïve subjects. However, there is no information on endothelial function in subjects with extremely low levels of LDL-C. The purpose of the present study was to determi...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/12/3796 |
| _version_ | 1797547001346260992 |
|---|---|
| author | Yuji Takaeko Masato Kajikawa Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yiming Han Yasuki Kihara Eisuke Hida Kazuaki Chayama Chikara Goto Yoshiki Aibara Farina Mohamad Yusoff Tatsuya Maruhashi Ayumu Nakashima Yukihito Higashi |
| author_facet | Yuji Takaeko Masato Kajikawa Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yiming Han Yasuki Kihara Eisuke Hida Kazuaki Chayama Chikara Goto Yoshiki Aibara Farina Mohamad Yusoff Tatsuya Maruhashi Ayumu Nakashima Yukihito Higashi |
| author_sort | Yuji Takaeko |
| collection | DOAJ |
| description | An elevation of serum low-density lipoprotein cholesterol (LDL-C) levels has been associated with endothelial dysfunction in statin naïve subjects. However, there is no information on endothelial function in subjects with extremely low levels of LDL-C. The purpose of the present study was to determine the relationship of LDL-C levels, especially low levels of LDL-C, with endothelial function. Endothelial function assessed by flow-mediated vasodilation (FMD) measurement and LDL-C levels were evaluated in 7120 subjects without lipid-lowering therapy. We divided the subjects into five groups by LDL-C levels: <70 mg/dL, 70–99 mg/dL, 100–119 md/dL, 120–139 mg/dL, and ≥140 mg/dL. FMD values were significantly smaller in subjects with LDL-C levels of ≥140 mg/dL than in those with LDL-C levels of 70–99 mg/dL and 100–119 mg/dL (<i>p</i> < 0.001 and <i>p</i> = 0.004, respectively). The FMD values in the LDL-C of <70 mg/dL group were not significantly different from those in the other groups. To evaluate the relationship of extremely low LDL-C levels with endothelial function, we divided the subjects with LDL-C of <70 mg/dL into those with LDL-C levels of <50 mg/dL and 50–69 mg/dL. FMD values were similar in the LDL-C <50 mg/dL group and ≥50 mg/dL group in the propensity score-matched population (<i>p</i> = 0.570). A significant benefit was not found in subjects with low LDL-C levels from the aspect of endothelial function. |
| first_indexed | 2024-03-10T14:37:15Z |
| format | Article |
| id | doaj.art-befbffdf184c45be8cb386d2b12581da |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:37:15Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-befbffdf184c45be8cb386d2b12581da2023-11-20T22:06:26ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01912379610.3390/jcm9123796Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering TherapyYuji Takaeko0Masato Kajikawa1Shinji Kishimoto2Takayuki Yamaji3Takahiro Harada4Yiming Han5Yasuki Kihara6Eisuke Hida7Kazuaki Chayama8Chikara Goto9Yoshiki Aibara10Farina Mohamad Yusoff11Tatsuya Maruhashi12Ayumu Nakashima13Yukihito Higashi14Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Biostatistics and Data Science, Graduate School of Medicine, Faculty of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, JapanDepartment of Physical Therapy, Hiroshima International University, Hiroshima 739-2695, JapanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Stem Cell Biology and Medicine, Graduate School of Biomedical and Health Sciences, Faculty of Medicine, Hiroshima University, Hiroshima 734-8553, JapanDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanAn elevation of serum low-density lipoprotein cholesterol (LDL-C) levels has been associated with endothelial dysfunction in statin naïve subjects. However, there is no information on endothelial function in subjects with extremely low levels of LDL-C. The purpose of the present study was to determine the relationship of LDL-C levels, especially low levels of LDL-C, with endothelial function. Endothelial function assessed by flow-mediated vasodilation (FMD) measurement and LDL-C levels were evaluated in 7120 subjects without lipid-lowering therapy. We divided the subjects into five groups by LDL-C levels: <70 mg/dL, 70–99 mg/dL, 100–119 md/dL, 120–139 mg/dL, and ≥140 mg/dL. FMD values were significantly smaller in subjects with LDL-C levels of ≥140 mg/dL than in those with LDL-C levels of 70–99 mg/dL and 100–119 mg/dL (<i>p</i> < 0.001 and <i>p</i> = 0.004, respectively). The FMD values in the LDL-C of <70 mg/dL group were not significantly different from those in the other groups. To evaluate the relationship of extremely low LDL-C levels with endothelial function, we divided the subjects with LDL-C of <70 mg/dL into those with LDL-C levels of <50 mg/dL and 50–69 mg/dL. FMD values were similar in the LDL-C <50 mg/dL group and ≥50 mg/dL group in the propensity score-matched population (<i>p</i> = 0.570). A significant benefit was not found in subjects with low LDL-C levels from the aspect of endothelial function.https://www.mdpi.com/2077-0383/9/12/3796low-density cholesterolendothelial functionflow-mediated vasodilationHypolipidemiaatherosclerosis |
| spellingShingle | Yuji Takaeko Masato Kajikawa Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yiming Han Yasuki Kihara Eisuke Hida Kazuaki Chayama Chikara Goto Yoshiki Aibara Farina Mohamad Yusoff Tatsuya Maruhashi Ayumu Nakashima Yukihito Higashi Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy Journal of Clinical Medicine low-density cholesterol endothelial function flow-mediated vasodilation Hypolipidemia atherosclerosis |
| title | Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy |
| title_full | Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy |
| title_fullStr | Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy |
| title_full_unstemmed | Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy |
| title_short | Low Levels of Low-Density Lipoprotein Cholesterol and Endothelial Function in Subjects without Lipid-Lowering Therapy |
| title_sort | low levels of low density lipoprotein cholesterol and endothelial function in subjects without lipid lowering therapy |
| topic | low-density cholesterol endothelial function flow-mediated vasodilation Hypolipidemia atherosclerosis |
| url | https://www.mdpi.com/2077-0383/9/12/3796 |
| work_keys_str_mv | AT yujitakaeko lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT masatokajikawa lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT shinjikishimoto lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT takayukiyamaji lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT takahiroharada lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT yiminghan lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT yasukikihara lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT eisukehida lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT kazuakichayama lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT chikaragoto lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT yoshikiaibara lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT farinamohamadyusoff lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT tatsuyamaruhashi lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT ayumunakashima lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy AT yukihitohigashi lowlevelsoflowdensitylipoproteincholesterolandendothelialfunctioninsubjectswithoutlipidloweringtherapy |