Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus
Top-down processes conveying contextual information play a major role in shaping odor representations within the olfactory system, yet the underlying mechanisms are poorly understood. The hippocampus (HPC) is a major source of olfactory top-down modulation, providing direct excitatory inputs to the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnana.2018.00012/full |
| _version_ | 1818357037392723968 |
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| author | Afif J. Aqrabawi Jun Chul Kim Jun Chul Kim |
| author_facet | Afif J. Aqrabawi Jun Chul Kim Jun Chul Kim |
| author_sort | Afif J. Aqrabawi |
| collection | DOAJ |
| description | Top-down processes conveying contextual information play a major role in shaping odor representations within the olfactory system, yet the underlying mechanisms are poorly understood. The hippocampus (HPC) is a major source of olfactory top-down modulation, providing direct excitatory inputs to the anterior olfactory nucleus (AON). However, HPC-AON projections remain uncharacterized. In an effort to understand how hippocampal inputs are distributed within the AON, we systematically outlined their organization using anterograde and retrograde tracing methods. We found that AON-projecting hippocampal pyramidal neurons are located mostly in the ventral two-thirds of the HPC and are organized topographically such that cells with a ventral to intermediate hippocampal point of origin terminate, respectively, at the medial to lateral AON. Our neuroanatomical findings suggest a potential role for the HPC in the early processing and contextualization of odors which merits further investigation. |
| first_indexed | 2024-12-13T20:06:44Z |
| format | Article |
| id | doaj.art-befc625c4e394ef6b1cada5bd36908c5 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-13T20:06:44Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-befc625c4e394ef6b1cada5bd36908c52022-12-21T23:33:01ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292018-02-011210.3389/fnana.2018.00012282117Topographic Organization of Hippocampal Inputs to the Anterior Olfactory NucleusAfif J. Aqrabawi0Jun Chul Kim1Jun Chul Kim2Department of Cell & Systems Biology, University of Toronto, Toronto, ON, CanadaDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON, CanadaDepartment of Psychology, University of Toronto, Toronto, ON, CanadaTop-down processes conveying contextual information play a major role in shaping odor representations within the olfactory system, yet the underlying mechanisms are poorly understood. The hippocampus (HPC) is a major source of olfactory top-down modulation, providing direct excitatory inputs to the anterior olfactory nucleus (AON). However, HPC-AON projections remain uncharacterized. In an effort to understand how hippocampal inputs are distributed within the AON, we systematically outlined their organization using anterograde and retrograde tracing methods. We found that AON-projecting hippocampal pyramidal neurons are located mostly in the ventral two-thirds of the HPC and are organized topographically such that cells with a ventral to intermediate hippocampal point of origin terminate, respectively, at the medial to lateral AON. Our neuroanatomical findings suggest a potential role for the HPC in the early processing and contextualization of odors which merits further investigation.http://journal.frontiersin.org/article/10.3389/fnana.2018.00012/fullAONtracingtopographyhippocampusolfactionanterograde |
| spellingShingle | Afif J. Aqrabawi Jun Chul Kim Jun Chul Kim Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus Frontiers in Neuroanatomy AON tracing topography hippocampus olfaction anterograde |
| title | Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus |
| title_full | Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus |
| title_fullStr | Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus |
| title_full_unstemmed | Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus |
| title_short | Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus |
| title_sort | topographic organization of hippocampal inputs to the anterior olfactory nucleus |
| topic | AON tracing topography hippocampus olfaction anterograde |
| url | http://journal.frontiersin.org/article/10.3389/fnana.2018.00012/full |
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