Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis
The retinal pigment epithelial(RPE)is composed of a monolayer of cuboidal cells lying between the retinal photoreceptor and the Bruch's membrane of the choroids. The normality in morphology and function of RPE is essential for photoreceptor. RPE cells have the functions of selectively transport...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2016-02-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2016/2/201602017.pdf |
| _version_ | 1811307195382366208 |
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| author | Shu-Ya Zhang Wei Kong Jun Kong |
| author_facet | Shu-Ya Zhang Wei Kong Jun Kong |
| author_sort | Shu-Ya Zhang |
| collection | DOAJ |
| description | The retinal pigment epithelial(RPE)is composed of a monolayer of cuboidal cells lying between the retinal photoreceptor and the Bruch's membrane of the choroids. The normality in morphology and function of RPE is essential for photoreceptor. RPE cells have the functions of selectively transporting nutrition, metabolic end products, ions and excess water, expressing and secreting various growth factors, involved in visual cycle, maintaining the blood-retinal barrier and phagocytosis of shed outer segments of photoreceptor cells. The blood-retinal barrier is indispensable for the maintaince of the retina homeostasis, so the dysfunction of the RPE cells contributes to variety of intraocular neovascular diease. This article reviews the roles of RPE in normal structure, secreting growth factors, maintaining the blood-retinal barrier and anti-angiogenesis. |
| first_indexed | 2024-04-13T09:00:15Z |
| format | Article |
| id | doaj.art-befccb5f7fab4e3f9a6527a76013d7a5 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-04-13T09:00:15Z |
| publishDate | 2016-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-befccb5f7fab4e3f9a6527a76013d7a52022-12-22T02:53:10ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232016-02-0116226526910.3980/j.issn.1672-5123.2016.2.17Functions of retinal pigment epithelial cell and its roles in anti-angiogenesisShu-Ya Zhang0Wei Kong1Jun Kong2The Fourth Affiliated Hospital of China Medical University, Ophthalmic Hospital of China Medical University,Shenyang 110001, Liaoning Province, ChinaDepartment of Ophthalmology, Shenyang the Fourth Hospital of People, Shenyang 110005, Liaoning Province, ChinaThe Fourth Affiliated Hospital of China Medical University, Ophthalmic Hospital of China Medical University,Shenyang 110001, Liaoning Province, ChinaThe retinal pigment epithelial(RPE)is composed of a monolayer of cuboidal cells lying between the retinal photoreceptor and the Bruch's membrane of the choroids. The normality in morphology and function of RPE is essential for photoreceptor. RPE cells have the functions of selectively transporting nutrition, metabolic end products, ions and excess water, expressing and secreting various growth factors, involved in visual cycle, maintaining the blood-retinal barrier and phagocytosis of shed outer segments of photoreceptor cells. The blood-retinal barrier is indispensable for the maintaince of the retina homeostasis, so the dysfunction of the RPE cells contributes to variety of intraocular neovascular diease. This article reviews the roles of RPE in normal structure, secreting growth factors, maintaining the blood-retinal barrier and anti-angiogenesis.http://ies.ijo.cn/cn_publish/2016/2/201602017.pdfretinal pigment epithelialblood-retinal barrierneovascularizationvascular endothelial growth factor |
| spellingShingle | Shu-Ya Zhang Wei Kong Jun Kong Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis Guoji Yanke Zazhi retinal pigment epithelial blood-retinal barrier neovascularization vascular endothelial growth factor |
| title | Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis |
| title_full | Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis |
| title_fullStr | Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis |
| title_full_unstemmed | Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis |
| title_short | Functions of retinal pigment epithelial cell and its roles in anti-angiogenesis |
| title_sort | functions of retinal pigment epithelial cell and its roles in anti angiogenesis |
| topic | retinal pigment epithelial blood-retinal barrier neovascularization vascular endothelial growth factor |
| url | http://ies.ijo.cn/cn_publish/2016/2/201602017.pdf |
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