Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda
Introduction: Following chronic inflammation and other disease specific factors, the risk of liver disease is believed to be higher among HIV-infected patients than in the general population despite shared risk factors. Understanding this differentiated burden and its drivers will inform policy and...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Dialogues in Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772653322000272 |
| _version_ | 1828168491745673216 |
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| author | Clara Wekesa Ponsiano Ocama Rosalind Parkes-Ratanshi Gregory D. Kirk |
| author_facet | Clara Wekesa Ponsiano Ocama Rosalind Parkes-Ratanshi Gregory D. Kirk |
| author_sort | Clara Wekesa |
| collection | DOAJ |
| description | Introduction: Following chronic inflammation and other disease specific factors, the risk of liver disease is believed to be higher among HIV-infected patients than in the general population despite shared risk factors. Understanding this differentiated burden and its drivers will inform policy and priority populations for intervention. Methods: This was a cross sectional study among 516 adults attending care clinics in Kampala Uganda. Significant liver fibrosis (SLF) was defined as liver stiffness measurement ≥7.2 KPa identified by Fibroscan®. Data analyses were stratified by HIV status and we performed logistic regression performed to identify correlates. Results: The prevalence of SLF was higher among HIV un-infected patients ((24% Vs 14%; p0.004). Overall HIV-uninfected patients were more likely to be overweight and or obese, with elevated serum cholesterol levels. Elevated measurement of fatty change in the liver (CAP scores >248 dB/m) was associated with SLF among HIV un-infected patients (OR 2.3 CI (1.0-5.2); p = 0.046). Low nadir CD4 counts (200cell/mm3) was predictive of SLF among HIV-infected patients (OR 3.3 CI (1.0-10.7); p = 0.05). Conclusion: The prevalence of SLF was unexpectedly higher among HIV un-infected than HIV affected patients attending care clinics in urban Uganda. This observed burden is most likely driven by non-alcoholic fatty liver disease (NAFLD) resulting from metabolic syndrome. |
| first_indexed | 2024-04-12T02:34:36Z |
| format | Article |
| id | doaj.art-befe4efbd8124a63ba6d7cc00fb6f5fc |
| institution | Directory Open Access Journal |
| issn | 2772-6533 |
| language | English |
| last_indexed | 2024-04-12T02:34:36Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Dialogues in Health |
| spelling | doaj.art-befe4efbd8124a63ba6d7cc00fb6f5fc2022-12-22T03:51:37ZengElsevierDialogues in Health2772-65332022-12-011100027Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban UgandaClara Wekesa0Ponsiano Ocama1Rosalind Parkes-Ratanshi2Gregory D. Kirk3Infectious Diseases Institute, Makerere University Kampala, Uganda; Corresponding author at: Infectious Diseases Institute, Makerere University, P.O. BOX 22418, Kampala, Uganda.Makerere University, College of Health Sciences Kampala, UgandaCambridge University, Institute of Public Health, Cambridge, UKJohn Hopkins University, Baltimore, USAIntroduction: Following chronic inflammation and other disease specific factors, the risk of liver disease is believed to be higher among HIV-infected patients than in the general population despite shared risk factors. Understanding this differentiated burden and its drivers will inform policy and priority populations for intervention. Methods: This was a cross sectional study among 516 adults attending care clinics in Kampala Uganda. Significant liver fibrosis (SLF) was defined as liver stiffness measurement ≥7.2 KPa identified by Fibroscan®. Data analyses were stratified by HIV status and we performed logistic regression performed to identify correlates. Results: The prevalence of SLF was higher among HIV un-infected patients ((24% Vs 14%; p0.004). Overall HIV-uninfected patients were more likely to be overweight and or obese, with elevated serum cholesterol levels. Elevated measurement of fatty change in the liver (CAP scores >248 dB/m) was associated with SLF among HIV un-infected patients (OR 2.3 CI (1.0-5.2); p = 0.046). Low nadir CD4 counts (200cell/mm3) was predictive of SLF among HIV-infected patients (OR 3.3 CI (1.0-10.7); p = 0.05). Conclusion: The prevalence of SLF was unexpectedly higher among HIV un-infected than HIV affected patients attending care clinics in urban Uganda. This observed burden is most likely driven by non-alcoholic fatty liver disease (NAFLD) resulting from metabolic syndrome.http://www.sciencedirect.com/science/article/pii/S2772653322000272Liver fibrosisFibroscan®HIV/AIDSSteatosisNAFLD |
| spellingShingle | Clara Wekesa Ponsiano Ocama Rosalind Parkes-Ratanshi Gregory D. Kirk Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda Dialogues in Health Liver fibrosis Fibroscan® HIV/AIDS Steatosis NAFLD |
| title | Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda |
| title_full | Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda |
| title_fullStr | Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda |
| title_full_unstemmed | Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda |
| title_short | Burden and correlates of significant liver fibrosis among HIV-infected and uninfected adults in urban Uganda |
| title_sort | burden and correlates of significant liver fibrosis among hiv infected and uninfected adults in urban uganda |
| topic | Liver fibrosis Fibroscan® HIV/AIDS Steatosis NAFLD |
| url | http://www.sciencedirect.com/science/article/pii/S2772653322000272 |
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