A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection.

Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell malignancies. However, whether lytic EBV infection also contributes to tumors is unclear, although the association between malaria infection and Burkitt lymphomas (BLs) may involve excessive lytic EBV replicatio...

Full description

Bibliographic Details
Main Authors:	Jillian A Bristol, Reza Djavadian, Emily R Albright, Carrie B Coleman, Makoto Ohashi, Mitchell Hayes, James C Romero-Masters, Elizabeth A Barlow, Paul J Farrell, Rosemary Rochford, Robert F Kalejta, Eric C Johannsen, Shannon C Kenney
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-07-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC6082571?pdf=render

Similar Items

Rta is the principal activator of Epstein-Barr virus epithelial lytic transcription.
by: Ahmed Ali, et al.
Published: (2022-09-01)

CAGE-seq analysis of Epstein-Barr virus lytic gene transcription: 3 kinetic classes from 2 mechanisms.
by: Reza Djavadian, et al.
Published: (2018-06-01)

An Epstein-Barr Virus-Encoded Protein Complex Requires an Origin of Lytic Replication In Cis to Mediate Late Gene Transcription.
by: Reza Djavadian, et al.
Published: (2016-06-01)

An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.
by: James C Romero-Masters, et al.
Published: (2018-08-01)

Urea-mediated cross-presentation of soluble Epstein-Barr virus BZLF1 protein.
by: Sascha Barabas, et al.
Published: (2008-11-01)

The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1.
by: Amanda R Robinson, et al.
Published: (2012-02-01)

B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection.
by: James C Romero-Masters, et al.
Published: (2020-02-01)

Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.
by: Jianmin Zuo, et al.
Published: (2011-12-01)

Design of Peptide Inhibitors That Bind the bZIP Domain of Epstein–Barr Virus Protein BZLF1
by: Chen, T. Scott, et al.
Published: (2015)

BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression.
by: Anne Woellmer, et al.
Published: (2012-09-01)

Epigenetic Modification of the Epstein-Barr Virus BZLF1 Promoter Regulates Viral Reactivation from Latency
by: Takayuki eMurata, et al.
Published: (2013-04-01)

Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells.
by: Dhananjay M Nawandar, et al.
Published: (2015-10-01)

Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis
by: Lee Fah Yap, et al.
Published: (2022-11-01)

ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells.
by: Nicholas Van Sciver, et al.
Published: (2021-11-01)

ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells
by: Nicholas Van Sciver, et al.
Published: (2021-11-01)

IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt's lymphoma cells.
by: Marc Jordi, et al.
Published: (2017-01-01)

Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus
by: Kelly L. Gorres, et al.
Published: (2016-05-01)

Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma
by: Rosemary Rochford
Published: (2016-01-01)

A role for the nucleosome assembly proteins TAF-Iβ and NAP1 in the activation of BZLF1 expression and Epstein-Barr virus reactivation.
by: Sheila Mansouri, et al.
Published: (2013-01-01)

Epstein–Barr Virus: How Its Lytic Phase Contributes to Oncogenesis
by: Quincy Rosemarie, et al.
Published: (2020-11-01)

Molecular Basis of Epstein–Barr Virus Latency Establishment and Lytic Reactivation
by: Takayuki Murata, et al.
Published: (2021-11-01)

EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice.
by: Chunrong Li, et al.
Published: (2020-06-01)

Methylation profiling of Epstein-Barr virus immediate-early gene promoters, <it>BZLF1 </it>and <it>BRLF1 </it>in tumors of epithelial, NK- and B-cell origins
by: Li Lili, et al.
Published: (2012-03-01)

Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells.
by: Jillian A Bristol, et al.
Published: (2022-04-01)

Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells
by: Jillian A. Bristol, et al.
Published: (2022-04-01)

Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
by: Drosu, Natalia C.
Published: (2020)

Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes.
by: Deo R Singh, et al.
Published: (2022-10-01)

Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes
by: Deo R. Singh, et al.
Published: (2022-10-01)

Arsenicals, the Integrated Stress Response, and Epstein–Barr Virus Lytic Gene Expression
by: Jaeyeun Lee, et al.
Published: (2021-04-01)

Replication Compartments—The Great Survival Strategy for Epstein–Barr Virus Lytic Replication
by: Atsuko Sugimoto
Published: (2022-04-01)

Inhibition of Epstein-Barr Virus Lytic Reactivation by the Atypical Antipsychotic Drug Clozapine
by: Abbie G. Anderson, et al.
Published: (2019-05-01)

ZEB1 regulates the latent-lytic switch in infection by Epstein-Barr virus.
by: Xianming Yu, et al.
Published: (2007-12-01)

EBV lytic proteins BZLF1 and BILF1 inhibit the expression of major histocompatibility complex in Raji cells
by: ZHENG Hongling, GUO Qingwei, ZHANG Wei, ZHANG Yan, HE Xingbo, YE Bing
Published: (2023-04-01)

Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53
by: Ghoda Lucy Y, et al.
Published: (2011-09-01)

Advancing therapeutic strategies for Epstein-Barr virus-associated malignancies through lytic reactivation
by: Haiqi Tan, et al.
Published: (2023-08-01)

A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells
by: Ina Ersing, et al.
Published: (2017-05-01)

Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas
by: Ming-Han Tsai, et al.
Published: (2013-10-01)

The Dual Functions of Andrographolide in the Epstein–Barr Virus-Positive Head-and-Neck Cancer Cells: The Inhibition of Lytic Reactivation of the Epstein–Barr Virus and the Induction of Cell Death
by: Chukkris Heawchaiyaphum, et al.
Published: (2023-11-01)

Tenofovir prodrugs potently inhibit Epstein–Barr virus lytic DNA replication by targeting the viral DNA polymerase
by: Drosu, Natalia C, et al.
Published: (2021)

Roles of Lytic Viral Replication and Co-Infections in the Oncogenesis and Immune Control of the Epstein–Barr Virus
by: Yun Deng, et al.
Published: (2021-05-01)