Stress granules: potential therapeutic targets for infectious and inflammatory diseases
Eukaryotic cells are stimulated by external pressure such as that derived from heat shock, oxidative stress, nutrient deficiencies, or infections, which induce the formation of stress granules (SGs) that facilitates cellular adaptation to environmental pressures. As aggregated products of the transl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145346/full |
| _version_ | 1827956002731851776 |
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| author | Wenyuan Li Yao Wang |
| author_facet | Wenyuan Li Yao Wang |
| author_sort | Wenyuan Li |
| collection | DOAJ |
| description | Eukaryotic cells are stimulated by external pressure such as that derived from heat shock, oxidative stress, nutrient deficiencies, or infections, which induce the formation of stress granules (SGs) that facilitates cellular adaptation to environmental pressures. As aggregated products of the translation initiation complex in the cytoplasm, SGs play important roles in cell gene expression and homeostasis. Infection induces SGs formation. Specifically, a pathogen that invades a host cell leverages the host cell translation machinery to complete the pathogen life cycle. In response, the host cell suspends translation, which leads to SGs formation, to resist pathogen invasion. This article reviews the production and function of SGs, the interaction between SGs and pathogens, and the relationship between SGs and pathogen-induced innate immunity to provide directions for further research into anti-infection and anti-inflammatory disease strategies. |
| first_indexed | 2024-04-09T14:56:45Z |
| format | Article |
| id | doaj.art-bf00f89b670d4bfb9589cdf819f95fcf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T14:56:45Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bf00f89b670d4bfb9589cdf819f95fcf2023-05-02T05:08:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11453461145346Stress granules: potential therapeutic targets for infectious and inflammatory diseasesWenyuan Li0Yao Wang1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaEukaryotic cells are stimulated by external pressure such as that derived from heat shock, oxidative stress, nutrient deficiencies, or infections, which induce the formation of stress granules (SGs) that facilitates cellular adaptation to environmental pressures. As aggregated products of the translation initiation complex in the cytoplasm, SGs play important roles in cell gene expression and homeostasis. Infection induces SGs formation. Specifically, a pathogen that invades a host cell leverages the host cell translation machinery to complete the pathogen life cycle. In response, the host cell suspends translation, which leads to SGs formation, to resist pathogen invasion. This article reviews the production and function of SGs, the interaction between SGs and pathogens, and the relationship between SGs and pathogen-induced innate immunity to provide directions for further research into anti-infection and anti-inflammatory disease strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145346/fullstress granulesinfectioninflammationinnate immunitytherapeutic targets |
| spellingShingle | Wenyuan Li Yao Wang Stress granules: potential therapeutic targets for infectious and inflammatory diseases Frontiers in Immunology stress granules infection inflammation innate immunity therapeutic targets |
| title | Stress granules: potential therapeutic targets for infectious and inflammatory diseases |
| title_full | Stress granules: potential therapeutic targets for infectious and inflammatory diseases |
| title_fullStr | Stress granules: potential therapeutic targets for infectious and inflammatory diseases |
| title_full_unstemmed | Stress granules: potential therapeutic targets for infectious and inflammatory diseases |
| title_short | Stress granules: potential therapeutic targets for infectious and inflammatory diseases |
| title_sort | stress granules potential therapeutic targets for infectious and inflammatory diseases |
| topic | stress granules infection inflammation innate immunity therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145346/full |
| work_keys_str_mv | AT wenyuanli stressgranulespotentialtherapeutictargetsforinfectiousandinflammatorydiseases AT yaowang stressgranulespotentialtherapeutictargetsforinfectiousandinflammatorydiseases |