UXT at the crossroads of cell death, immunity and neurodegenerative diseases
The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the reg...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1179947/full |
| _version_ | 1797844283915501568 |
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| author | Pengzhe Han Shaojian Mo Shaojian Mo Zhengwang Wang Jiale Xu Xifeng Fu Xifeng Fu Yanzhang Tian Yanzhang Tian |
| author_facet | Pengzhe Han Shaojian Mo Shaojian Mo Zhengwang Wang Jiale Xu Xifeng Fu Xifeng Fu Yanzhang Tian Yanzhang Tian |
| author_sort | Pengzhe Han |
| collection | DOAJ |
| description | The ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the regulation of cell metabolism, thereby affecting tumor progression. UXT also maintains immune homeostasis and reduces proteotoxicity in neuro-degenerative diseases through selective autophagy and molecular chaperones. Herein, we review and further elucidate the mechanisms by which UXT affects the regulation of cell death, maintenance of immune homeostasis, and neurodegenerative diseases and discuss the possible UXT involvement in the regulation of ferroptosis and immunogenic cell death, and targeting it to improve cancer treatment outcomes by regulating cell death and immune surveillance. |
| first_indexed | 2024-04-09T17:19:48Z |
| format | Article |
| id | doaj.art-bf01b2f2b74343efa4eaf55442a553e8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T17:19:48Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bf01b2f2b74343efa4eaf55442a553e82023-04-19T05:21:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11799471179947UXT at the crossroads of cell death, immunity and neurodegenerative diseasesPengzhe Han0Shaojian Mo1Shaojian Mo2Zhengwang Wang3Jiale Xu4Xifeng Fu5Xifeng Fu6Yanzhang Tian7Yanzhang Tian8Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaThe ubiquitous expressed transcript (UXT), a member of the prefoldin-like protein family, modulates regulated cell death (RCD) such as apoptosis and autophagy-mediated cell death through nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), P53, P62, and methylation, and is involved in the regulation of cell metabolism, thereby affecting tumor progression. UXT also maintains immune homeostasis and reduces proteotoxicity in neuro-degenerative diseases through selective autophagy and molecular chaperones. Herein, we review and further elucidate the mechanisms by which UXT affects the regulation of cell death, maintenance of immune homeostasis, and neurodegenerative diseases and discuss the possible UXT involvement in the regulation of ferroptosis and immunogenic cell death, and targeting it to improve cancer treatment outcomes by regulating cell death and immune surveillance.https://www.frontiersin.org/articles/10.3389/fonc.2023.1179947/fullUXTapoptosisimmunityneurodegenerative diseaseautophagy |
| spellingShingle | Pengzhe Han Shaojian Mo Shaojian Mo Zhengwang Wang Jiale Xu Xifeng Fu Xifeng Fu Yanzhang Tian Yanzhang Tian UXT at the crossroads of cell death, immunity and neurodegenerative diseases Frontiers in Oncology UXT apoptosis immunity neurodegenerative disease autophagy |
| title | UXT at the crossroads of cell death, immunity and neurodegenerative diseases |
| title_full | UXT at the crossroads of cell death, immunity and neurodegenerative diseases |
| title_fullStr | UXT at the crossroads of cell death, immunity and neurodegenerative diseases |
| title_full_unstemmed | UXT at the crossroads of cell death, immunity and neurodegenerative diseases |
| title_short | UXT at the crossroads of cell death, immunity and neurodegenerative diseases |
| title_sort | uxt at the crossroads of cell death immunity and neurodegenerative diseases |
| topic | UXT apoptosis immunity neurodegenerative disease autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1179947/full |
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