The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasio...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/11/1739 |
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| author | Junya Ke Jiangfeng Ye Mingqing Li Zhiling Zhu |
| author_facet | Junya Ke Jiangfeng Ye Mingqing Li Zhiling Zhu |
| author_sort | Junya Ke |
| collection | DOAJ |
| description | Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions. |
| first_indexed | 2024-03-10T05:40:35Z |
| format | Article |
| id | doaj.art-bf028fd4eaf1406c93d00aa724c08e64 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T05:40:35Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-bf028fd4eaf1406c93d00aa724c08e642023-11-22T22:35:38ZengMDPI AGBiomolecules2218-273X2021-11-011111173910.3390/biom11111739The Role of Matrix Metalloproteinases in Endometriosis: A Potential TargetJunya Ke0Jiangfeng Ye1Mingqing Li2Zhiling Zhu3Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDivision of Obstetrics and Gynecology, KK Women’s and Children’s Hospital, Singapore 229899, SingaporeDepartment of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDepartment of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaEndometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions.https://www.mdpi.com/2218-273X/11/11/1739matrix metalloproteinasesendometriosisfunctionpotential value |
| spellingShingle | Junya Ke Jiangfeng Ye Mingqing Li Zhiling Zhu The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target Biomolecules matrix metalloproteinases endometriosis function potential value |
| title | The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target |
| title_full | The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target |
| title_fullStr | The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target |
| title_full_unstemmed | The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target |
| title_short | The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target |
| title_sort | role of matrix metalloproteinases in endometriosis a potential target |
| topic | matrix metalloproteinases endometriosis function potential value |
| url | https://www.mdpi.com/2218-273X/11/11/1739 |
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