Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls
Introduction: Proton magnetic resonance spectroscopy (PrMRS) detects changes in brain metabolite levels in vivo. Aim: The aim of the present study was to evaluate the brain metabolites choline ((Cho), creatine (Cr), and N-acetyl aspartate (NAA) in lesion free normal appearing white...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2022-10-01
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| Series: | Folia Medica |
| Online Access: | https://foliamedica.bg/article/66002/download/pdf/ |
| _version_ | 1828159232284819456 |
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| author | Vasilena Petrova Krasimir Genov |
| author_facet | Vasilena Petrova Krasimir Genov |
| author_sort | Vasilena Petrova |
| collection | DOAJ |
| description | Introduction: Proton magnetic resonance spectroscopy (PrMRS) detects changes in brain metabolite levels in vivo. Aim: The aim of the present study was to evaluate the brain metabolites choline ((Cho), creatine (Cr), and N-acetyl aspartate (NAA) in lesion free normal appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls. The second aim was to explore the impact of sex on brain metabolite changes. Materials and methods: Fifty RRMS patients received PrMRS evaluation of their brain NAWM regions. The results were compared with the findings in 28 healthy demographically matched controls. Results: We found elevated levels of Cho, Cr, and NAA in NAWM of MS patients in comparison with healthy controls. The NAA/Cr and Cr/NAA ratios were collated. A statistically significant difference between both groups was found only for NAA/Cr and Cr/NAA ratios. It is due to metabolite changes in the female MS patients. Conclusions: The results of the present study using PrMRS proved metabolic changes in NAWM. Accompanying pathological process should be assumed, preceding plaques of demyelination. The gender impact needs further investigation. |
| first_indexed | 2024-04-11T23:57:47Z |
| format | Article |
| id | doaj.art-bf0585c492ca4f529e7b195216601c2c |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-04-11T23:57:47Z |
| publishDate | 2022-10-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-bf0585c492ca4f529e7b195216601c2c2022-12-22T03:56:19ZengPensoft PublishersFolia Medica1314-21432022-10-0164574675310.3897/folmed.64.e6600266002Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controlsVasilena Petrova0Krasimir Genov1Clinic of Nerve Diseases, Military Medical AcademyClinic of Nerve Diseases, SMHATIntroduction: Proton magnetic resonance spectroscopy (PrMRS) detects changes in brain metabolite levels in vivo. Aim: The aim of the present study was to evaluate the brain metabolites choline ((Cho), creatine (Cr), and N-acetyl aspartate (NAA) in lesion free normal appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls. The second aim was to explore the impact of sex on brain metabolite changes. Materials and methods: Fifty RRMS patients received PrMRS evaluation of their brain NAWM regions. The results were compared with the findings in 28 healthy demographically matched controls. Results: We found elevated levels of Cho, Cr, and NAA in NAWM of MS patients in comparison with healthy controls. The NAA/Cr and Cr/NAA ratios were collated. A statistically significant difference between both groups was found only for NAA/Cr and Cr/NAA ratios. It is due to metabolite changes in the female MS patients. Conclusions: The results of the present study using PrMRS proved metabolic changes in NAWM. Accompanying pathological process should be assumed, preceding plaques of demyelination. The gender impact needs further investigation.https://foliamedica.bg/article/66002/download/pdf/ |
| spellingShingle | Vasilena Petrova Krasimir Genov Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls Folia Medica |
| title | Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls |
| title_full | Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls |
| title_fullStr | Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls |
| title_full_unstemmed | Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls |
| title_short | Normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls |
| title_sort | normal appearing white matter metabolite pattern and sex differences in multiple sclerosis patients compared to healthy controls |
| url | https://foliamedica.bg/article/66002/download/pdf/ |
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