Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease?
Non-tuberculous mycobacteria (NTM) are increasingly a cause of human respiratory tract colonization and mycobacterial lung disease (NTM-LD), especially in patients with chronic lung diseases. The aim of the present study was to find the factors predictive of NTM-LD in patients with obstructive lung...
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MDPI AG
2020-07-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/7/424 |
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| author | Monika Szturmowicz Karina Oniszh Dorota Wyrostkiewicz Piotr Radwan-Rohrenschef Dorota Filipczak Anna Zabost |
| author_facet | Monika Szturmowicz Karina Oniszh Dorota Wyrostkiewicz Piotr Radwan-Rohrenschef Dorota Filipczak Anna Zabost |
| author_sort | Monika Szturmowicz |
| collection | DOAJ |
| description | Non-tuberculous mycobacteria (NTM) are increasingly a cause of human respiratory tract colonization and mycobacterial lung disease (NTM-LD), especially in patients with chronic lung diseases. The aim of the present study was to find the factors predictive of NTM-LD in patients with obstructive lung diseases and NTM respiratory isolates. A total of 839 isolates of NTM, obtained from 161 patients between 2010 and 2020 in a single pulmonary unit, have been retrospectively reviewed. Of these isolates, 73 concerned 36 patients with obstructive lung diseases (COPD-26, asthma-3, COPD/asthma overlap syndrome-7). NTM-LD was recognized according to the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA) criteria in 17 patients, colonization in 19. Lower BMI, elevated body temperature on admission, infiltrative/cavitary lesions on chest CT, and NTM species other than <i>Mycobacterium gordonae</i> were the significant predictors of NTM-LD recognition. Based on the above-mentioned predictive factors, an original scoring system was implemented. The diagnostic utility of the scoring system was higher than that of single parameters. We conclude that NTM-LD prediction in patients with obstructive lung diseases and positive respiratory isolates is difficult. A scoring system based on clinical, radiological and microbiological characteristics was capable of facilitating the differential diagnosis, but it needs further validation in a larger study group. |
| first_indexed | 2024-03-10T18:21:09Z |
| format | Article |
| id | doaj.art-bf05aea96a034c9388216607a0e364eb |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T18:21:09Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-bf05aea96a034c9388216607a0e364eb2023-11-20T07:21:51ZengMDPI AGAntibiotics2079-63822020-07-019742410.3390/antibiotics9070424Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease?Monika Szturmowicz0Karina Oniszh1Dorota Wyrostkiewicz2Piotr Radwan-Rohrenschef3Dorota Filipczak4Anna Zabost5Ist Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, 01-138 Warsaw, PolandDepartment of Radiology, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, 01-138 Warsaw, PolandIst Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, 01-138 Warsaw, PolandIst Department of Lung Diseases, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, 01-138 Warsaw, PolandDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, 01-138 Warsaw, PolandDepartment of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, 01-138 Warsaw, PolandNon-tuberculous mycobacteria (NTM) are increasingly a cause of human respiratory tract colonization and mycobacterial lung disease (NTM-LD), especially in patients with chronic lung diseases. The aim of the present study was to find the factors predictive of NTM-LD in patients with obstructive lung diseases and NTM respiratory isolates. A total of 839 isolates of NTM, obtained from 161 patients between 2010 and 2020 in a single pulmonary unit, have been retrospectively reviewed. Of these isolates, 73 concerned 36 patients with obstructive lung diseases (COPD-26, asthma-3, COPD/asthma overlap syndrome-7). NTM-LD was recognized according to the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA) criteria in 17 patients, colonization in 19. Lower BMI, elevated body temperature on admission, infiltrative/cavitary lesions on chest CT, and NTM species other than <i>Mycobacterium gordonae</i> were the significant predictors of NTM-LD recognition. Based on the above-mentioned predictive factors, an original scoring system was implemented. The diagnostic utility of the scoring system was higher than that of single parameters. We conclude that NTM-LD prediction in patients with obstructive lung diseases and positive respiratory isolates is difficult. A scoring system based on clinical, radiological and microbiological characteristics was capable of facilitating the differential diagnosis, but it needs further validation in a larger study group.https://www.mdpi.com/2079-6382/9/7/424non-tuberculous mycobacteriachronic obstructive pulmonary diseaseasthma<i>Mycobacterium gordonae</i>chest computed tomographybody mass index |
| spellingShingle | Monika Szturmowicz Karina Oniszh Dorota Wyrostkiewicz Piotr Radwan-Rohrenschef Dorota Filipczak Anna Zabost Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease? Antibiotics non-tuberculous mycobacteria chronic obstructive pulmonary disease asthma <i>Mycobacterium gordonae</i> chest computed tomography body mass index |
| title | Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease? |
| title_full | Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease? |
| title_fullStr | Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease? |
| title_full_unstemmed | Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease? |
| title_short | Non-Tuberculous Mycobacteria in Respiratory Specimens of Patients with Obstructive Lung Diseases—Colonization or Disease? |
| title_sort | non tuberculous mycobacteria in respiratory specimens of patients with obstructive lung diseases colonization or disease |
| topic | non-tuberculous mycobacteria chronic obstructive pulmonary disease asthma <i>Mycobacterium gordonae</i> chest computed tomography body mass index |
| url | https://www.mdpi.com/2079-6382/9/7/424 |
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