RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

A pair of kinases, RIPK1 and RIPK3, as well as the RIPK3 substrate MLKL cause a form of programmed necrotic cell death in mammals termed necroptosis. We report here that male reproductive organs of both Ripk3- and Mlkl-knockout mice retain ‘youthful’ morphology and function into advanced age, while...

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Bibliographic Details
Main Authors: Dianrong Li, Lingjun Meng, Tao Xu, Yaning Su, Xiao Liu, Zhiyuan Zhang, Xiaodong Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
aging
necroptosis
apoptosis
testis
spermatogonia
Online Access:https://elifesciences.org/articles/27692

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