Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology and function and muscle weakness has not been direct...

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Bibliographic Details
Main Authors: Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Skeletal muscle
Mitochondria
MnSOD
Reactive oxygen species
Fibre branching
Hyperplasia
Online Access:https://doi.org/10.1002/jcsm.12375

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