Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population.
To compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [(18)F]AV-45 positron emission tomography (PET).[(18)F]AV-45 PET was performed in 11 CN, 13 aMCI, and 12 AD subjects to compare the cereb...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3597555?pdf=render |
| _version_ | 1818480072904933376 |
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| author | Kuo-Lun Huang Kun-Ju Lin Ing-Tsung Hsiao Hung-Chou Kuo Wen-Chuin Hsu Wen-Li Chuang Mei-Ping Kung Shiaw-Pyng Wey Chia-Ju Hsieh Yau-Yau Wai Tzu-Chen Yen Chin-Chang Huang |
| author_facet | Kuo-Lun Huang Kun-Ju Lin Ing-Tsung Hsiao Hung-Chou Kuo Wen-Chuin Hsu Wen-Li Chuang Mei-Ping Kung Shiaw-Pyng Wey Chia-Ju Hsieh Yau-Yau Wai Tzu-Chen Yen Chin-Chang Huang |
| author_sort | Kuo-Lun Huang |
| collection | DOAJ |
| description | To compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [(18)F]AV-45 positron emission tomography (PET).[(18)F]AV-45 PET was performed in 11 CN, 13 aMCI, and 12 AD subjects to compare the cerebral cortex-to-whole cerebellum standard uptake value ratios (SUVRs) of global and individual volumes of interest (VOIs) cerebral cortex. The correlation between global cortical [(18)F]AV-45 SUVRs and Mini-Mental State Examination (MMSE) scores was analyzed.The global cortical [(18)F]AV-45 SUVRs were significantly different among the CN (1.08±0.08), aMCI (1.27±0.06), and AD groups (1.34±0.13) (p = 0.0003) with amyloidosis positivity rates of 9%, 62%, and 92% in the three groups respectively. Compared to CN subjects, AD subjects had higher SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, and posterior cingulate areas; while aMCI subjects had higher values in the global cortical, precuneus, frontal, occipital and posterior cingulate areas. There were negative correlations of MMSE scores with SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, posterior cingulate and anterior cingulate areas on a combined subject pool of the three groups after age and education attainment adjustment.Amyloid deposition occurs relatively early in precuneus, frontal and posterior cingulate in aMCI subjects. Higher [(18)F]AV-45 accumulation is present in parietal, occipital and temporal gyri in AD subjects compared to the aMCI group. Significant correlation between MMSE scores and [(18)F]AV-45 SUVRs can be observed among CN, aMCI and AD subjects. |
| first_indexed | 2024-12-10T11:18:23Z |
| format | Article |
| id | doaj.art-bf06f28ef1094ae28b56697642cdf7d4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T11:18:23Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-bf06f28ef1094ae28b56697642cdf7d42022-12-22T01:51:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5897410.1371/journal.pone.0058974Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population.Kuo-Lun HuangKun-Ju LinIng-Tsung HsiaoHung-Chou KuoWen-Chuin HsuWen-Li ChuangMei-Ping KungShiaw-Pyng WeyChia-Ju HsiehYau-Yau WaiTzu-Chen YenChin-Chang HuangTo compare the neocortical amyloid loads among cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) subjects with [(18)F]AV-45 positron emission tomography (PET).[(18)F]AV-45 PET was performed in 11 CN, 13 aMCI, and 12 AD subjects to compare the cerebral cortex-to-whole cerebellum standard uptake value ratios (SUVRs) of global and individual volumes of interest (VOIs) cerebral cortex. The correlation between global cortical [(18)F]AV-45 SUVRs and Mini-Mental State Examination (MMSE) scores was analyzed.The global cortical [(18)F]AV-45 SUVRs were significantly different among the CN (1.08±0.08), aMCI (1.27±0.06), and AD groups (1.34±0.13) (p = 0.0003) with amyloidosis positivity rates of 9%, 62%, and 92% in the three groups respectively. Compared to CN subjects, AD subjects had higher SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, and posterior cingulate areas; while aMCI subjects had higher values in the global cortical, precuneus, frontal, occipital and posterior cingulate areas. There were negative correlations of MMSE scores with SUVRs in the global cortical, precuneus, frontal, parietal, occipital, temporal, posterior cingulate and anterior cingulate areas on a combined subject pool of the three groups after age and education attainment adjustment.Amyloid deposition occurs relatively early in precuneus, frontal and posterior cingulate in aMCI subjects. Higher [(18)F]AV-45 accumulation is present in parietal, occipital and temporal gyri in AD subjects compared to the aMCI group. Significant correlation between MMSE scores and [(18)F]AV-45 SUVRs can be observed among CN, aMCI and AD subjects.http://europepmc.org/articles/PMC3597555?pdf=render |
| spellingShingle | Kuo-Lun Huang Kun-Ju Lin Ing-Tsung Hsiao Hung-Chou Kuo Wen-Chuin Hsu Wen-Li Chuang Mei-Ping Kung Shiaw-Pyng Wey Chia-Ju Hsieh Yau-Yau Wai Tzu-Chen Yen Chin-Chang Huang Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. PLoS ONE |
| title | Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. |
| title_full | Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. |
| title_fullStr | Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. |
| title_full_unstemmed | Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. |
| title_short | Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population. |
| title_sort | regional amyloid deposition in amnestic mild cognitive impairment and alzheimer s disease evaluated by 18f av 45 positron emission tomography in chinese population |
| url | http://europepmc.org/articles/PMC3597555?pdf=render |
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