Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus
The use of medicinal plants in the management of diabetes mellitus (DM) is extensively reported. However, there is still very limited information on the role of these plants as markers of oxidative stress in DM. This current review evaluated the effect of <i>Amaranthus spinosus</i>, <...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/9/1830 |
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| author | Wendy N. Phoswa Kabelo Mokgalaboni |
| author_facet | Wendy N. Phoswa Kabelo Mokgalaboni |
| author_sort | Wendy N. Phoswa |
| collection | DOAJ |
| description | The use of medicinal plants in the management of diabetes mellitus (DM) is extensively reported. However, there is still very limited information on the role of these plants as markers of oxidative stress in DM. This current review evaluated the effect of <i>Amaranthus spinosus</i>, <i>Amaranthus hybridus,</i> and <i>Abelmoschus esculentus</i> on markers of oxidative stress in rodent models of DM. Current findings indicate that these plants have the potential to reduce prominent markers of oxidative stress, such as serum malondialdehyde and thiobarbituric acid-reactive substances, while increasing enzymes that act as antioxidants, such as superoxide dismutase, catalase, glutathione, and glutathione peroxidase. This may reduce reactive oxygen species and further ameliorate oxidative stress in DM. Although the potential benefits of these plants are acknowledged in rodent models, there is still a lack of evidence showing their efficacy against oxidative stress in diabetic patients. Therefore, we recommend future clinical studies in DM populations, particularly in Africa, to evaluate the potential effects of these plants. Such studies would contribute to enhancing our understanding of the significance of incorporating these plants into dietary practices for the prevention and management of DM. |
| first_indexed | 2024-03-10T22:33:21Z |
| format | Article |
| id | doaj.art-bf06f3d0a8294666996b6bfdea62a213 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T22:33:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-bf06f3d0a8294666996b6bfdea62a2132023-11-19T11:36:54ZengMDPI AGLife2075-17292023-08-01139183010.3390/life13091830Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes MellitusWendy N. Phoswa0Kabelo Mokgalaboni1Department of Life and Consumer Sciences, University of South Africa (UNISA), Science Campus, Private Bag X6, Florida, Roodepoort 1710, South AfricaDepartment of Life and Consumer Sciences, University of South Africa (UNISA), Science Campus, Private Bag X6, Florida, Roodepoort 1710, South AfricaThe use of medicinal plants in the management of diabetes mellitus (DM) is extensively reported. However, there is still very limited information on the role of these plants as markers of oxidative stress in DM. This current review evaluated the effect of <i>Amaranthus spinosus</i>, <i>Amaranthus hybridus,</i> and <i>Abelmoschus esculentus</i> on markers of oxidative stress in rodent models of DM. Current findings indicate that these plants have the potential to reduce prominent markers of oxidative stress, such as serum malondialdehyde and thiobarbituric acid-reactive substances, while increasing enzymes that act as antioxidants, such as superoxide dismutase, catalase, glutathione, and glutathione peroxidase. This may reduce reactive oxygen species and further ameliorate oxidative stress in DM. Although the potential benefits of these plants are acknowledged in rodent models, there is still a lack of evidence showing their efficacy against oxidative stress in diabetic patients. Therefore, we recommend future clinical studies in DM populations, particularly in Africa, to evaluate the potential effects of these plants. Such studies would contribute to enhancing our understanding of the significance of incorporating these plants into dietary practices for the prevention and management of DM.https://www.mdpi.com/2075-1729/13/9/1830antioxidantsdiabetes mellitus<i>Amaranthus</i><i>Abelmoschus esculentus</i>oxidative stress |
| spellingShingle | Wendy N. Phoswa Kabelo Mokgalaboni Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus Life antioxidants diabetes mellitus <i>Amaranthus</i> <i>Abelmoschus esculentus</i> oxidative stress |
| title | Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus |
| title_full | Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus |
| title_fullStr | Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus |
| title_full_unstemmed | Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus |
| title_short | Comprehensive Overview of the Effects of <i>Amaranthus</i> and <i>Abelmoschus esculentus</i> on Markers of Oxidative Stress in Diabetes Mellitus |
| title_sort | comprehensive overview of the effects of i amaranthus i and i abelmoschus esculentus i on markers of oxidative stress in diabetes mellitus |
| topic | antioxidants diabetes mellitus <i>Amaranthus</i> <i>Abelmoschus esculentus</i> oxidative stress |
| url | https://www.mdpi.com/2075-1729/13/9/1830 |
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