Evaluation of Salivary Levels of Pyridinoline Cross Linked Carboxyterminal Telopeptide of Type I Collagen (Ictp) in Periodontal Health and Disease
Background: Traditional parameters (Pocket depth, bleeding on probing, clinical attachment loss, radiographic findings) have been used for a long time for the assessment of periodontal disease conditions. However, these parameters only indicate towards the periodontal damage that has already tak...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6498/12689_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Traditional parameters (Pocket depth, bleeding
on probing, clinical attachment loss, radiographic findings) have
been used for a long time for the assessment of periodontal
disease conditions. However, these parameters only indicate
towards the periodontal damage that has already taken place
but do not give any idea regarding the current status of the
periodontal health or disease. Hence, the present study is
aimed at evaluating the concentration of the bone biomarker
ICTP in saliva, which can give a better real time assessment of
periodontal health and disease.
Materials and Methods: Forty three patients were selected
and divided into three groups based on the recorded clinical
parameters of probing pocket depth, attachment loss and
bleeding on probing. Group I (Healthy, n = 11), Group II
(Gingivitis, n = 17), Group III (Periodontitis. n = 15). Salivary
samples were collected before scaling and root planning to
avoid contamination by blood. ICTP levels were evaluated in
the salivary samples by using enzyme linked immunosorbent
assay (ELISA).
Statistical analysis used: Kruskal Wallis test was used to
compare the mean ICTP level of the three groups.
Results: ICTP was detected in all the samples. Highest mean
ICTP concentrations in saliva were obtained for group III
(periodontitis group) and the lowest mean ICTP concentrations
were seen in group I (healthy group). This suggests that the
level of ICTP in saliva increases proportionally from periodontal
health to diseased conditions (gingivitis & periodontitis).
Conclusion: There is a substantial increase in the salivary
concentration of ICTP in chronic periodontitis patients than in
gingivitis and healthy patients. Salivary ICTP levels were the
maximum in chronic periodontitis patients followed by gingivitis
patients and the least in healthy individuals. ICTP may be
considered as a biomarker in periodontal disease progression. |
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| ISSN: | 2249-782X 0973-709X |