Dynamical alterations of brain function and gut microbiome in weight loss
ObjectiveIntermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis.MethodsIn this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was us...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269548/full |
| _version_ | 1827578499744923648 |
|---|---|
| author | Jing Zhou Xiaoling Wu Tianyuan Xiang Fei Liu Hui Gao Li Tong Bin Yan Zhonglin Li Chi Zhang Linyuan Wang Lei Ou Zhongxia Li Zhongxia Li Wen Wang Tingting Yang Fengyun Li Huimin Ma Xiaojuan Zhao Na Mi Ziya Yu Canhui Lan Qi Wang Hao Li Liming Wang Xiaoning Wang Yongli Li Qiang Zeng |
| author_facet | Jing Zhou Xiaoling Wu Tianyuan Xiang Fei Liu Hui Gao Li Tong Bin Yan Zhonglin Li Chi Zhang Linyuan Wang Lei Ou Zhongxia Li Zhongxia Li Wen Wang Tingting Yang Fengyun Li Huimin Ma Xiaojuan Zhao Na Mi Ziya Yu Canhui Lan Qi Wang Hao Li Liming Wang Xiaoning Wang Yongli Li Qiang Zeng |
| author_sort | Jing Zhou |
| collection | DOAJ |
| description | ObjectiveIntermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis.MethodsIn this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was used to determine the activity of brain regions. Metagenomic sequencing was performed to identify differentially abundant gut microbes and pathways in from fecal samples.ResultsOur results showed that IER longitudinally reduced the activity of obese-related brain regions at different timepoints, including the inferior frontal orbital gyrus in the cognitive control circuit, the putamen in the emotion and learning circuit, and the anterior cingulate cortex in the sensory circuit. IER longitudinally reduced E. coli abundance across multiple timepoints while elevating the abundance of obesity-related Faecalibacterium prausnitzii, Parabacteroides distasonis, and Bacterokles uniformis. Correlation analysis revealed longitudinally correlations between gut bacteria abundance alterations and brain activity changes.ConclusionsThere was dynamical alteration of BGM axis (the communication of E. coli with specific brain regions) during the weight loss under the IER. |
| first_indexed | 2024-03-08T21:47:28Z |
| format | Article |
| id | doaj.art-bf08aeb603c747949f81214dda643589 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T21:47:28Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-bf08aeb603c747949f81214dda6435892023-12-20T07:47:45ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-12-011310.3389/fcimb.2023.12695481269548Dynamical alterations of brain function and gut microbiome in weight lossJing Zhou0Xiaoling Wu1Tianyuan Xiang2Fei Liu3Hui Gao4Li Tong5Bin Yan6Zhonglin Li7Chi Zhang8Linyuan Wang9Lei Ou10Zhongxia Li11Zhongxia Li12Wen Wang13Tingting Yang14Fengyun Li15Huimin Ma16Xiaojuan Zhao17Na Mi18Ziya Yu19Canhui Lan20Qi Wang21Hao Li22Liming Wang23Xiaoning Wang24Yongli Li25Qiang Zeng26Henan Provincial Research Center of Clinical Medicine of Nephropathy, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, ChinaDepartment of Nuclear Medicine, Henan Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, ChinaHealth Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaInstitute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaHenan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, ChinaHenan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, ChinaHenan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, ChinaDepartment of Radiology, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaHenan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, ChinaHenan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, ChinaHealth Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaBYHEALTH Institute of Nutrition & Health, BYHEALTH Co. Ltd, Guangzhou, Guangdong, ChinaDepartment of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Nutrition, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan, Zhengzhou, ChinaDepartment of Nutrition, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan, Zhengzhou, China0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, ChinaHenan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China1Beijing Rexinchang Biotechnology Research Institute Co. Ltd, Beijing, China2Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, Gansu, China3Department of Health Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, ChinaInstitute of Microbiology, Chinese Academy of Sciences, Beijing, China4The Institute of Geriatrics, The State Clinic Center for Geriatrics & The State Key Laboratory of Kidney, The People’s Liberation Army (PLA) General Hospital, Beijing, China5Department of Health Management, Henan Key Laboratory of Chronic Disease Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, ChinaHealth Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaObjectiveIntermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis.MethodsIn this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was used to determine the activity of brain regions. Metagenomic sequencing was performed to identify differentially abundant gut microbes and pathways in from fecal samples.ResultsOur results showed that IER longitudinally reduced the activity of obese-related brain regions at different timepoints, including the inferior frontal orbital gyrus in the cognitive control circuit, the putamen in the emotion and learning circuit, and the anterior cingulate cortex in the sensory circuit. IER longitudinally reduced E. coli abundance across multiple timepoints while elevating the abundance of obesity-related Faecalibacterium prausnitzii, Parabacteroides distasonis, and Bacterokles uniformis. Correlation analysis revealed longitudinally correlations between gut bacteria abundance alterations and brain activity changes.ConclusionsThere was dynamical alteration of BGM axis (the communication of E. coli with specific brain regions) during the weight loss under the IER.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269548/fullbrain-gut-microbiome axisweight lossfunctional magnetic resonance imagingintermittent energy restrictionmetagenomics |
| spellingShingle | Jing Zhou Xiaoling Wu Tianyuan Xiang Fei Liu Hui Gao Li Tong Bin Yan Zhonglin Li Chi Zhang Linyuan Wang Lei Ou Zhongxia Li Zhongxia Li Wen Wang Tingting Yang Fengyun Li Huimin Ma Xiaojuan Zhao Na Mi Ziya Yu Canhui Lan Qi Wang Hao Li Liming Wang Xiaoning Wang Yongli Li Qiang Zeng Dynamical alterations of brain function and gut microbiome in weight loss Frontiers in Cellular and Infection Microbiology brain-gut-microbiome axis weight loss functional magnetic resonance imaging intermittent energy restriction metagenomics |
| title | Dynamical alterations of brain function and gut microbiome in weight loss |
| title_full | Dynamical alterations of brain function and gut microbiome in weight loss |
| title_fullStr | Dynamical alterations of brain function and gut microbiome in weight loss |
| title_full_unstemmed | Dynamical alterations of brain function and gut microbiome in weight loss |
| title_short | Dynamical alterations of brain function and gut microbiome in weight loss |
| title_sort | dynamical alterations of brain function and gut microbiome in weight loss |
| topic | brain-gut-microbiome axis weight loss functional magnetic resonance imaging intermittent energy restriction metagenomics |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269548/full |
| work_keys_str_mv | AT jingzhou dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT xiaolingwu dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT tianyuanxiang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT feiliu dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT huigao dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT litong dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT binyan dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT zhonglinli dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT chizhang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT linyuanwang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT leiou dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT zhongxiali dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT zhongxiali dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT wenwang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT tingtingyang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT fengyunli dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT huiminma dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT xiaojuanzhao dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT nami dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT ziyayu dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT canhuilan dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT qiwang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT haoli dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT limingwang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT xiaoningwang dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT yonglili dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss AT qiangzeng dynamicalalterationsofbrainfunctionandgutmicrobiomeinweightloss |