Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of multidrug therapy to produce a durable cure. The reasons necessitating long treatment times are complex and multifactorial. However, one major difficulty of treating TB is the resistance of the infecting b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.997283/full |
| _version_ | 1798030416636018688 |
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| author | Nicholas C. Poulton Jeremy M. Rock |
| author_facet | Nicholas C. Poulton Jeremy M. Rock |
| author_sort | Nicholas C. Poulton |
| collection | DOAJ |
| description | Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of multidrug therapy to produce a durable cure. The reasons necessitating long treatment times are complex and multifactorial. However, one major difficulty of treating TB is the resistance of the infecting bacterium, Mycobacterium tuberculosis (Mtb), to many distinct classes of antimicrobials. This review will focus on the major gaps in our understanding of intrinsic drug resistance in Mtb and how functional and chemical-genetics can help close those gaps. A better understanding of intrinsic drug resistance will help lay the foundation for strategies to disarm and circumvent these mechanisms to develop more potent antitubercular therapies. |
| first_indexed | 2024-04-11T19:39:52Z |
| format | Article |
| id | doaj.art-bf094f16b5034145aaa5bbcd70bf90d1 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T19:39:52Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-bf094f16b5034145aaa5bbcd70bf90d12022-12-22T04:06:44ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-10-011210.3389/fcimb.2022.997283997283Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosisNicholas C. PoultonJeremy M. RockTuberculosis (TB) is among the most difficult infections to treat, requiring several months of multidrug therapy to produce a durable cure. The reasons necessitating long treatment times are complex and multifactorial. However, one major difficulty of treating TB is the resistance of the infecting bacterium, Mycobacterium tuberculosis (Mtb), to many distinct classes of antimicrobials. This review will focus on the major gaps in our understanding of intrinsic drug resistance in Mtb and how functional and chemical-genetics can help close those gaps. A better understanding of intrinsic drug resistance will help lay the foundation for strategies to disarm and circumvent these mechanisms to develop more potent antitubercular therapies.https://www.frontiersin.org/articles/10.3389/fcimb.2022.997283/fulltuberculosisintrinsic resistancechemical geneticsdrug repurposingdrug discovery |
| spellingShingle | Nicholas C. Poulton Jeremy M. Rock Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis Frontiers in Cellular and Infection Microbiology tuberculosis intrinsic resistance chemical genetics drug repurposing drug discovery |
| title | Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis |
| title_full | Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis |
| title_fullStr | Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis |
| title_full_unstemmed | Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis |
| title_short | Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis |
| title_sort | unraveling the mechanisms of intrinsic drug resistance in mycobacterium tuberculosis |
| topic | tuberculosis intrinsic resistance chemical genetics drug repurposing drug discovery |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.997283/full |
| work_keys_str_mv | AT nicholascpoulton unravelingthemechanismsofintrinsicdrugresistanceinmycobacteriumtuberculosis AT jeremymrock unravelingthemechanismsofintrinsicdrugresistanceinmycobacteriumtuberculosis |