Regulation of TIA-1 Condensates: Zn2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation

Regulation of TIA-1 Condensates: Zn2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation

Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs and protein-protein interactions. However, the f...

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Bibliographic Details
Main Authors: Danella L. West, Fionna E. Loughlin, Francisco Rivero-Rodríguez, Naveen Vankadari, Alejandro Velázquez-Cruz, Laura Corrales-Guerrero, Irene Díaz-Moreno, Jacqueline A. Wilce
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
TIA1
RNA binding protein
liquid-liquid phase separation
prion-like domain
RRM
amyloid fibril
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.960806/full

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