Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma

Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma

Hepatocellular carcinoma is the seventh most common type of cancer in the world, with limited treatment options. A promising strategy to treat cancer is to associate chemotherapeutics and plant bioactive compounds. Here, we examined whether diallyl disulfide (DADS; 50–200 μM) and sorafenib (SORA; 8...

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Bibliographic Details
Main Authors: Ana Rita Thomazela Machado, Katiuska Tuttis, Patrick Wellington da Silva Santos, Alexandre Ferro Aissa, Lusânia Maria Greggi Antunes
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
liver cancer
nutraceutical
<i>Allium sativum</i> L.
DNA damage
nutrigenomics
Online Access:https://www.mdpi.com/1999-4923/14/12/2582

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