Evaluating genomic polygenic risk scores for childhood acute lymphoblastic leukemia in Latinos

Evaluating genomic polygenic risk scores for childhood acute lymphoblastic leukemia in Latinos

Summary: The utility of polygenic risk score (PRS) models has not been comprehensively evaluated for childhood acute lymphoblastic leukemia (ALL), the most common type of cancer in children. Previous PRS models for ALL were based on significant loci observed in genome-wide association studies (GWASs...

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Main Authors: Soyoung Jeon, Ying Chu Lo, Libby M. Morimoto, Catherine Metayer, Xiaomei Ma, Joseph L. Wiemels, Adam J. de Smith, Charleston W.K. Chiang
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:HGG Advances
Subjects:
acute lymphoblastic leukemia
latinos
polygenic risk scores
risk prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247723000714

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