Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles
Sequentially Pd-catalyzed processes are excellent entries to heterocycle synthesis. The broad mechanistic variety combined with often very mild reaction conditions allow the concatenation of elementary organic and organometallic steps to novel sequences in the sense of one-pot domino and multicompon...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Applied Sciences |
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| Online Access: | http://www.mdpi.com/2076-3417/5/4/1803 |
| _version_ | 1818962519002185728 |
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| author | Timo Lessing Thomas J. J. Müller |
| author_facet | Timo Lessing Thomas J. J. Müller |
| author_sort | Timo Lessing |
| collection | DOAJ |
| description | Sequentially Pd-catalyzed processes are excellent entries to heterocycle synthesis. The broad mechanistic variety combined with often very mild reaction conditions allow the concatenation of elementary organic and organometallic steps to novel sequences in the sense of one-pot domino and multicomponent reactions. Given the numerous opportunities of alkyne coordination and their Pd-mediated transformations, alkynylation and carbometallation play a key role, both for purely organometallic sequences as well as in those processes that are intercepted by cyclocondensation. Pd-catalyzed aminations also find more and more entry into novel heterocycle syntheses based upon this theme. |
| first_indexed | 2024-12-20T12:30:36Z |
| format | Article |
| id | doaj.art-bf148c784eb94839be4cd232e58c6628 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-12-20T12:30:36Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-bf148c784eb94839be4cd232e58c66282022-12-21T19:40:43ZengMDPI AGApplied Sciences2076-34172015-12-01541803183610.3390/app5041803app5041803Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of HeterocyclesTimo Lessing0Thomas J. J. Müller1Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, GermanyInstitut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, GermanySequentially Pd-catalyzed processes are excellent entries to heterocycle synthesis. The broad mechanistic variety combined with often very mild reaction conditions allow the concatenation of elementary organic and organometallic steps to novel sequences in the sense of one-pot domino and multicomponent reactions. Given the numerous opportunities of alkyne coordination and their Pd-mediated transformations, alkynylation and carbometallation play a key role, both for purely organometallic sequences as well as in those processes that are intercepted by cyclocondensation. Pd-catalyzed aminations also find more and more entry into novel heterocycle syntheses based upon this theme.http://www.mdpi.com/2076-3417/5/4/1803cyclizationcyclocondensationdomino reactionsmolecular diversitymulticomponent reactionssynthetic methods |
| spellingShingle | Timo Lessing Thomas J. J. Müller Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles Applied Sciences cyclization cyclocondensation domino reactions molecular diversity multicomponent reactions synthetic methods |
| title | Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles |
| title_full | Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles |
| title_fullStr | Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles |
| title_full_unstemmed | Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles |
| title_short | Sequentially Palladium-Catalyzed Processes in One-Pot Syntheses of Heterocycles |
| title_sort | sequentially palladium catalyzed processes in one pot syntheses of heterocycles |
| topic | cyclization cyclocondensation domino reactions molecular diversity multicomponent reactions synthetic methods |
| url | http://www.mdpi.com/2076-3417/5/4/1803 |
| work_keys_str_mv | AT timolessing sequentiallypalladiumcatalyzedprocessesinonepotsynthesesofheterocycles AT thomasjjmuller sequentiallypalladiumcatalyzedprocessesinonepotsynthesesofheterocycles |